终生情感与中年认知功能：前瞻性出生队列研究
Lifetime affect and midlife cognitive function: prospective birth cohort study.
作者信息
Richards M, Barnett J H, Xu M K, Croudace T J, Gaysina D, Kuh D, Jones P B
机构信息
M. Richards, PhD, MRC Unit for Lifelong Health and Ageing, University College London; J. H. Barnett, PhD, Department of Psychiatry, University of Cambridge, and Cambridge Cognition Ltd, Cambridge; M. K. Xu, PhD, Department of Psychiatry, University of Cambridge, Cambridge; T. J. Croudace, PhD, Department of Health Sciences and Hull York Medical School, University of York, York; D. Gaysina, PhD, School of Psychology, University of Sussex, Falmer; D. Kuh, PhD, MRC Unit for Lifelong Health and Ageing, University College London; P. B. Jones, MD, PhD, Department of Psychiatry, University of Cambridge, Cambridge, UK, and the MRC National Survey of Health and Development scientific and data collection team.
出版信息
Br J Psychiatry. 2014 Mar;204(3):194-9. doi: 10.1192/bjp.bp.113.128942. Epub 2013 Dec 19.
BACKGROUND
Recurrent affective problems are predictive of cognitive impairment, but the timing and directionality, and the nature of the cognitive impairment, are unclear.
AIMS
To test prospective associations between life-course affective symptoms and cognitive function in late middle age.
METHOD
A total of 1668 men and women were drawn from the Medical Research Council National Survey of Health and Development (the British 1946 birth cohort). Longitudinal affective symptoms spanning age 13-53 years served as predictors; outcomes consisted of self-reported memory problems at 60-64 years and decline in memory and information processing from age 53 to 60-64 years.
RESULTS
Regression analyses revealed no clear pattern of association between longitudinal affective symptoms and decline in cognitive test scores, after adjusting for gender, childhood cognitive ability, education and midlife socioeconomic status. In contrast, affective symptoms were strongly, diffusely and independently associated with self-reported memory problems.
CONCLUSIONS
Affective symptoms are more clearly associated with self-reported memory problems in late midlife than with objectively measured cognitive performance.
背景
复发性情感问题可预测认知障碍，但认知障碍的发生时间、方向性以及其本质尚不清楚。
目的
检验中年后期生活历程中的情感症状与认知功能之间的前瞻性关联。
方法
从医学研究委员会全国健康与发展调查（英国1946年出生队列）中选取了1668名男性和女性。以13至53岁期间的纵向情感症状作为预测因素；结果包括60至64岁时自我报告的记忆问题，以及53岁至60至64岁期间记忆和信息处理能力的下降。
结果
在对性别、儿童期认知能力、教育程度和中年社会经济地位进行调整后，回归分析显示纵向情感症状与认知测试分数下降之间没有明显的关联模式。相比之下，情感症状与自我报告的记忆问题密切、广泛且独立相关。
结论
在中年后期，情感症状与自我报告的记忆问题的关联比与客观测量的认知表现的关联更为明显。
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