相似文献
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Cytosolic cleaved PINK1 represses Parkin translocation to mitochondria and mitophagy.细胞质切割的 PINK1 抑制 Parkin 向线粒体的易位和线粒体自噬。
EMBO Rep. 2014 Jan;15(1):86-93. doi: 10.1002/embr.201337294. Epub 2013 Dec 15.
2
Nitric oxide induction of Parkin translocation in PTEN-induced putative kinase 1 (PINK1) deficiency: functional role of neuronal nitric oxide synthase during mitophagy.一氧化氮在PTEN诱导的假定激酶1（PINK1）缺乏时诱导帕金蛋白易位：神经元型一氧化氮合酶在有丝分裂自噬过程中的功能作用
J Biol Chem. 2015 Apr 17;290(16):10325-35. doi: 10.1074/jbc.M114.624767. Epub 2015 Feb 25.
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Effect of endogenous mutant and wild-type PINK1 on Parkin in fibroblasts from Parkinson disease patients.帕金森病患者成纤维细胞中内源性突变型和野生型 PINK1 对 Parkin 的影响。
Hum Mol Genet. 2010 Aug 15;19(16):3124-37. doi: 10.1093/hmg/ddq215. Epub 2010 May 27.
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N-degron-mediated degradation and regulation of mitochondrial PINK1 kinase.N 连接肽介导的线粒体 PINK1 激酶降解和调控
Curr Genet. 2020 Aug;66(4):693-701. doi: 10.1007/s00294-020-01062-2. Epub 2020 Mar 10.
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Short mitochondrial ARF triggers Parkin/PINK1-dependent mitophagy.短小的线粒体ARF触发帕金蛋白/PTEN诱导激酶1依赖的线粒体自噬。
J Biol Chem. 2014 Oct 24;289(43):29519-30. doi: 10.1074/jbc.M114.607150. Epub 2014 Sep 12.
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PINK1-mediated phosphorylation of the Parkin ubiquitin-like domain primes mitochondrial translocation of Parkin and regulates mitophagy.PINK1 介导的 Parkin 泛素样结构域磷酸化使 Parkin 向线粒体易位并调节线粒体自噬。
Sci Rep. 2012;2:1002. doi: 10.1038/srep01002. Epub 2012 Dec 19.
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Role of PINK1 binding to the TOM complex and alternate intracellular membranes in recruitment and activation of the E3 ligase Parkin.PTEN-induced putative kinase 1（PINK1）与 TOM 复合物和替代的细胞内膜结合在募集和激活 E3 连接酶 Parkin 中的作用。
Dev Cell. 2012 Feb 14;22(2):320-33. doi: 10.1016/j.devcel.2011.12.014. Epub 2012 Jan 25.
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PTEN-L is a novel protein phosphatase for ubiquitin dephosphorylation to inhibit PINK1-Parkin-mediated mitophagy.PTEN-L 是一种新型的泛素去磷酸化蛋白磷酸酶，可抑制 PINK1-Parkin 介导的线粒体自噬。
Cell Res. 2018 Aug;28(8):787-802. doi: 10.1038/s41422-018-0056-0. Epub 2018 Jun 22.
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A specific subset of E2 ubiquitin-conjugating enzymes regulate Parkin activation and mitophagy differently.E2泛素结合酶的一个特定亚群对帕金森蛋白激活和线粒体自噬的调节方式不同。
J Cell Sci. 2014 Aug 15;127(Pt 16):3488-504. doi: 10.1242/jcs.147520. Epub 2014 Jun 13.
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Reactive oxygen species trigger Parkin/PINK1 pathway-dependent mitophagy by inducing mitochondrial recruitment of Parkin.活性氧通过诱导Parkin的线粒体募集来触发Parkin/PINK1途径依赖性线粒体自噬。
J Biol Chem. 2017 Oct 6;292(40):16697-16708. doi: 10.1074/jbc.M117.787739. Epub 2017 Aug 28.
引用本文的文献
1
Secretory mitophagy: an extracellular vesicle-mediated adaptive mechanism for cancer cell survival under oxidative stress.分泌性线粒体自噬：一种细胞外囊泡介导的癌细胞在氧化应激下存活的适应性机制。
Front Cell Dev Biol. 2025 Jan 30;12:1490902. doi: 10.3389/fcell.2024.1490902. eCollection 2024.
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Calcium-mediated regulation of mitophagy: implications in neurodegenerative diseases.钙介导的线粒体自噬调控：对神经退行性疾病的影响
NPJ Metab Health Dis. 2025;3(1):4. doi: 10.1038/s44324-025-00049-2. Epub 2025 Feb 3.
3
Mitochondrial destabilization in tendinopathy and potential therapeutic strategies.肌腱病中的线粒体不稳定及潜在治疗策略
J Orthop Translat. 2024 Oct 3;49:49-61. doi: 10.1016/j.jot.2024.09.003. eCollection 2024 Nov.
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Liver Cell Mitophagy in Metabolic Dysfunction-Associated Steatotic Liver Disease and Liver Fibrosis.代谢功能障碍相关脂肪性肝病和肝纤维化中的肝细胞线粒体自噬
Antioxidants (Basel). 2024 Jun 15;13(6):729. doi: 10.3390/antiox13060729.
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Formoterol Acting via β2-Adrenoreceptor Restores Mitochondrial Dysfunction Caused by Parkinson's Disease-Related UQCRC1 Mutation and Improves Mitochondrial Homeostasis Including Dynamic and Transport.福莫特罗通过β2-肾上腺素能受体发挥作用，可恢复帕金森病相关UQCRC1突变引起的线粒体功能障碍，并改善包括动态变化和转运在内的线粒体稳态。
Biology (Basel). 2024 Mar 30;13(4):231. doi: 10.3390/biology13040231.
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Disruption of Mitophagy Flux through the PARL-PINK1 Pathway by CHCHD10 Mutations or CHCHD10 Depletion.通过 PARL-PINK1 通路的 CHCHD10 突变或 CHCHD10 耗竭导致的线粒体自噬通量的破坏。
Cells. 2023 Dec 7;12(24):2781. doi: 10.3390/cells12242781.
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The mystery of phospho-Drp1 with four adaptors in cell cycle: when mitochondrial fission couples to cell fate decisions.磷酸化 Drp1 与四个衔接蛋白在细胞周期中的奥秘：线粒体裂变如何与细胞命运决定偶联。
Cell Cycle. 2023 Nov;22(21-22):2485-2503. doi: 10.1080/15384101.2023.2289753. Epub 2024 Jan 18.
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Parkinson's Disease: Are PINK1 Activators Inching Closer to the Clinic?帕金森病：PINK1激活剂离临床应用更近了吗？
ACS Med Chem Lett. 2023 Jun 15;14(7):870-874. doi: 10.1021/acsmedchemlett.3c00070. eCollection 2023 Jul 13.
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A comprehensive review of stroke-related signaling pathways and treatment in western medicine and traditional Chinese medicine.中西医中与中风相关的信号通路及治疗的综合综述。
Front Neurosci. 2023 Jun 7;17:1200061. doi: 10.3389/fnins.2023.1200061. eCollection 2023.
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PINK1-Dependent Mitophagy Inhibits Elevated Ubiquitin Phosphorylation Caused by Mitochondrial Damage.PINK1 依赖性线粒体自噬抑制线粒体损伤引起的泛素磷酸化升高。
J Med Chem. 2023 Jun 8;66(11):7645-7656. doi: 10.1021/acs.jmedchem.3c00555. Epub 2023 May 29.
本文引用的文献
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A neo-substrate that amplifies catalytic activity of parkinson's-disease-related kinase PINK1.一种可增强帕金森病相关激酶 PINK1 催化活性的新型底物。
Cell. 2013 Aug 15;154(4):737-47. doi: 10.1016/j.cell.2013.07.030.
2
Pink1 kinase and its membrane potential (Deltaψ)-dependent cleavage product both localize to outer mitochondrial membrane by unique targeting mode.Pink1 激酶及其膜电位 (Δψ)-依赖性裂解产物均通过独特的靶向模式定位于外线粒体膜。
J Biol Chem. 2012 Jun 29;287(27):22969-87. doi: 10.1074/jbc.M112.365700. Epub 2012 Apr 30.
3
Mitochondrial processing peptidase regulates PINK1 processing, import and Parkin recruitment.线粒体加工肽酶调节 PINK1 的加工、导入和 Parkin 的募集。
EMBO Rep. 2012 Apr;13(4):378-85. doi: 10.1038/embor.2012.14.
4
Mitochondrial autophagy in cells with mtDNA mutations results from synergistic loss of transmembrane potential and mTORC1 inhibition.线粒体自噬在携带 mtDNA 突变的细胞中发生，是由于跨膜电位协同丧失和 mTORC1 抑制的结果。
Hum Mol Genet. 2012 Mar 1;21(5):978-90. doi: 10.1093/hmg/ddr529. Epub 2011 Nov 11.
5
Mitochondria: the next (neurode)generation.线粒体：下一代（神经）。
Neuron. 2011 Jun 23;70(6):1033-53. doi: 10.1016/j.neuron.2011.06.003.
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A new cytosolic pathway from a Parkinson disease-associated kinase, BRPK/PINK1: activation of AKT via mTORC2.一种来自帕金森病相关激酶 BRPK/PINK1 的新胞质途径：通过 mTORC2 激活 AKT。
J Biol Chem. 2011 Mar 4;286(9):7182-9. doi: 10.1074/jbc.M110.179390. Epub 2010 Dec 21.
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PINK1 cleavage at position A103 by the mitochondrial protease PARL.由线粒体蛋白酶 PARL 在位置 A103 对 PINK1 的切割。
Hum Mol Genet. 2011 Mar 1;20(5):867-79. doi: 10.1093/hmg/ddq526. Epub 2010 Dec 6.
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Mitochondrial membrane potential regulates PINK1 import and proteolytic destabilization by PARL.线粒体膜电位调节 PINK1 通过 PARL 的导入和蛋白水解失稳。
J Cell Biol. 2010 Nov 29;191(5):933-42. doi: 10.1083/jcb.201008084.
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Parkin overexpression selects against a deleterious mtDNA mutation in heteroplasmic cybrid cells.Parkin 过表达选择不利于异质细胞系中线粒体 DNA 突变的存在。
Proc Natl Acad Sci U S A. 2010 Jun 29;107(26):11835-40. doi: 10.1073/pnas.0914569107. Epub 2010 Jun 14.
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Effect of endogenous mutant and wild-type PINK1 on Parkin in fibroblasts from Parkinson disease patients.帕金森病患者成纤维细胞中内源性突变型和野生型 PINK1 对 Parkin 的影响。
Hum Mol Genet. 2010 Aug 15;19(16):3124-37. doi: 10.1093/hmg/ddq215. Epub 2010 May 27.
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