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帕金森病：PINK1激活剂离临床应用更近了吗？

Parkinson's Disease: Are PINK1 Activators Inching Closer to the Clinic?

作者信息

Mehellou Youcef

机构信息

Cardiff School of Pharmacy and Pharmaceutical Sciences, Cardiff University, Redwood Building, King Edward VII Avenue, Cardiff CF10 3NB, U.K.

出版信息

ACS Med Chem Lett. 2023 Jun 15;14(7):870-874. doi: 10.1021/acsmedchemlett.3c00070. eCollection 2023 Jul 13.

DOI:10.1021/acsmedchemlett.3c00070
PMID:37465300
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10350934/
Abstract

The activation of PINK1 by small molecules has emerged as a promising strategy in treating Parkinson's disease (PD). Recent progress in this area has raised excitement around PINK1 activators as PD treatments, and herein we offer insight into these developments and their potential to deliver much needed novel PD treatments.

摘要

通过小分子激活PINK1已成为治疗帕金森病（PD）的一种有前景的策略。该领域的最新进展引发了人们对PINK1激活剂作为PD治疗方法的兴奋之情，在此我们深入探讨这些进展以及它们提供急需的新型PD治疗方法的潜力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/08a5/10350934/9cfe3723c2d0/ml3c00070_0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/08a5/10350934/480aad22d6d4/ml3c00070_0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/08a5/10350934/9cfe3723c2d0/ml3c00070_0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/08a5/10350934/480aad22d6d4/ml3c00070_0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/08a5/10350934/9cfe3723c2d0/ml3c00070_0002.jpg

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Mitochondria and Parkinson's Disease: Clinical, Molecular, and Translational Aspects.线粒体与帕金森病：临床、分子和转化方面。
J Parkinsons Dis. 2021;11(1):45-60. doi: 10.3233/JPD-201981.
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Neurological disorders and mitochondria.神经紊乱与线粒体。
Mol Aspects Med. 2020 Feb;71:100826. doi: 10.1016/j.mam.2019.10.003. Epub 2019 Oct 17.
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Mitophagy inhibits amyloid-β and tau pathology and reverses cognitive deficits in models of Alzheimer's disease.自噬抑制淀粉样β和 tau 病理，逆转阿尔茨海默病模型中的认知障碍。
Nat Neurosci. 2019 Mar;22(3):401-412. doi: 10.1038/s41593-018-0332-9. Epub 2019 Feb 11.
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