Harvey V J, Slevin M L, Aherne G W, Littleton P, Johnston A, Wrigley P F
J Clin Oncol. 1987 Apr;5(4):648-50. doi: 10.1200/JCO.1987.5.4.648.
The phase specificity and short half-life of bleomycin make it likely that it would be more effective when administered by continuous infusion. This is supported by studies using cell lines, as well as by animal studies and clinical experience in humans. This study was conducted to compare the pharmacokinetics of intravenous (IV) and subcutaneous infusions of bleomycin. The serum concentrations of bleomycin were measured using a sensitive and specific radioimmunoassay. The results demonstrate similar plasma concentrations and area under the curve for both routes. The subcutaneous infusions were well tolerated, without local discomfort or excoriation. Subcutaneous infusion of bleomycin may thus offer a practical alternative to IV infusions and can be administered to patients who are ambulatory and out of hospital.
博来霉素的阶段特异性和短半衰期使得持续输注给药时可能更有效。这得到了使用细胞系的研究以及动物研究和人类临床经验的支持。本研究旨在比较博来霉素静脉输注和皮下输注的药代动力学。使用灵敏且特异的放射免疫分析法测量博来霉素的血清浓度。结果表明两种给药途径的血浆浓度和曲线下面积相似。皮下输注耐受性良好，无局部不适或皮肤破损。因此，皮下输注博来霉素可能为静脉输注提供一种实用的替代方法，并且可以用于能够走动且不住院的患者。
