Slevin M L, Harvey V J, Aherne G W, Burton N K, Johnston A, Wrigley P F
Cancer Chemother Pharmacol. 1984;13(1):19-21. doi: 10.1007/BF00401440.
Experimental and clinical evidence indicates that bleomycin by continuous infusion is superior to intermittent administration. Continuous infusion is less convenient, however. It has been suggested that a suspension of bleomycin in sesame oil, given by IM injection, simulates a continuous infusion. The pharmacokinetics of this formulation have been compared with those of bleomycin in saline following IM injection, in six patients. The pharmacokinetic profiles of the two formulations were similar. The only difference between the profiles was the long terminal half-life at very low concentrations between 12 and 48 h after injection of the oil suspension. This difference is of unknown, but doubtful, clinical significance.
实验和临床证据表明，持续输注博来霉素优于间歇性给药。然而，持续输注不太方便。有人提出，通过肌内注射给予的博来霉素芝麻油混悬液模拟了持续输注。在六名患者中，已将该制剂的药代动力学与肌内注射后生理盐水溶液中博来霉素的药代动力学进行了比较。两种制剂的药代动力学曲线相似。曲线之间的唯一差异是注射油混悬液后12至48小时内极低浓度下的长终末半衰期。这种差异的临床意义尚不清楚，但值得怀疑。
