人牙龈朗格汉斯细胞和角质形成细胞在体外对Ⅱ类（DR和DQ）抗原的差异表达

Differential expression of Class II (DR & DQ) antigens by human gingival Langerhans' cells and keratinocytes in vitro.

作者信息

Walsh L J, Seymour G J, Powell R N

出版信息

J Oral Pathol. 1987 Jan;16(1):27-30. doi: 10.1111/j.1600-0714.1987.tb00672.x.

DOI:10.1111/j.1600-0714.1987.tb00672.x

Abstract

The expression of the Class II products DR and DQ on human gingival epithelium was examined using immunofluorescence and immunoperoxidase staining. Differential expression of Class II antigens was seen in chronic gingivitis in adults, with T6(+) DR(+) cells being more numerous than T6(+) DQ(+) cells. The periodontopathic organism Fusobacterium nucleatum (FN) induced DQ expression on Langerhans' cells (LC) during in vitro explant culture of gingival tissue. This effect was mimicked by endotoxin (LPS) from F. nucleatum and by E. coli LPS. These results indicate that differential expression of Class II products, a feature of chronic gingival inflammation, may result from the action of LPS on gingival LC.

摘要

采用免疫荧光和免疫过氧化物酶染色法检测了人类牙龈上皮中Ⅱ类产物DR和DQ的表达。在成人慢性牙龈炎中可见Ⅱ类抗原的差异表达，T6(+)DR(+)细胞比T6(+)DQ(+)细胞数量更多。在牙龈组织的体外植块培养过程中，牙周病原菌具核梭杆菌（FN）诱导朗格汉斯细胞（LC）表达DQ。具核梭杆菌的内毒素（LPS）和大肠杆菌LPS可模拟这种效应。这些结果表明，Ⅱ类产物的差异表达作为慢性牙龈炎症的一个特征，可能是LPS作用于牙龈LC的结果。