Walsh L J, Seymour G J, Savage N W
J Dent Res. 1986 Mar;65(3):390-3. doi: 10.1177/00220345860650030301.
The expression of the Class II antigens HLA-DR and HLA-DQ in human oral mucosa was examined in health and in the presence of inflammation. DQ antigens were detected on dendritic intra-epithelial cells which expressed the Langerhans cells (LC) phenotype T6+, DR+. In healthy gingiva, DR and DQ were co-expressed on Langerhans cells, whereas in an experimental gingivitis (day 8), more LC expressed DR than DQ. Absolute LC numbers were increased in inflammation. Traumatic ulceration of the buccal mucosa resulted in a decrease in the density of T6-, DR-, and DQ-positive cells. Repopulation of migrating and regenerated epithelium was complete 10 days after ulcer induction. Disparity between DR and DQ expression was seen in both normal buccal mucosa and throughout the ulcer healing period. These results are in agreement with the reported sequence of Class II antigen expression on lymphoid cells.
研究了人类口腔黏膜中Ⅱ类抗原HLA - DR和HLA - DQ在健康状态及炎症存在时的表达情况。在表达朗格汉斯细胞（LC）表型T6 +、DR +的树突状上皮内细胞上检测到DQ抗原。在健康牙龈中，DR和DQ在朗格汉斯细胞上共同表达，而在实验性牙龈炎（第8天）时，表达DR的LC比表达DQ的更多。炎症时LC的绝对数量增加。颊黏膜的创伤性溃疡导致T6 -、DR -和DQ阳性细胞密度降低。溃疡诱导10天后，迁移和再生上皮的重新形成完成。在正常颊黏膜及整个溃疡愈合期均可见DR和DQ表达的差异。这些结果与报道的淋巴样细胞上Ⅱ类抗原表达顺序一致。
