Greene Deanna J, Schlaggar Bradley L, Black Kevin J
Department of Psychiatry, Washington University School of Medicine ; Department of Radiology, Washington University School of Medicine.
Department of Psychiatry, Washington University School of Medicine ; Department of Radiology, Washington University School of Medicine ; Department of Neurology, Washington University School of Medicine ; Department of Anatomy & Neurobiology, Washington University School of Medicine ; Department of Pediatrics, Washington University School of Medicine.
Curr Dev Disord Rep. 2015 Dec;2(4):300-308. doi: 10.1007/s40474-015-0062-6. Epub 2015 Aug 19.
Tourette Syndrome (ts) is a developmental neuropsychiatric disorder of the central nervous system defined by the presence of chronic tics. While investigations of the underlying brain mechanisms have provided valuable information, a complete understanding of the pathophysiology of ts remains elusive. Neuroimaging methods provide remarkable tools for examining the human brain, and have been used to study brain structure and function in ts. In this article, we review ts neuroimaging studies published in 2014-2015. We highlight a number of noteworthy studies due to their innovative methods and interesting findings. Yet, we note that many of the recent studies share common concerns, specifically susceptibility to motion artifacts and modest sample sizes. Thus, we encourage future work to carefully address potential methodological confounds and to study larger samples to increase the potential for replicable results.
抽动秽语综合征（TS）是一种中枢神经系统的发育性神经精神障碍，其特征为存在慢性抽动。虽然对潜在脑机制的研究提供了有价值的信息，但对TS病理生理学的全面理解仍然难以捉摸。神经影像学方法为检查人类大脑提供了卓越的工具，并已用于研究TS患者的脑结构和功能。在本文中，我们回顾了2014 - 2015年发表的TS神经影像学研究。由于其创新方法和有趣的发现，我们重点介绍了一些值得注意的研究。然而，我们注意到最近的许多研究都存在共同的问题，特别是对运动伪影的敏感性和样本量较小。因此，我们鼓励未来的研究仔细解决潜在的方法学混杂因素，并研究更大的样本，以增加获得可重复结果的可能性。
