Bagherzadeh Ataollah, Nejati-Afkham Afshin, Tajallizade-Khoob Yaser, Shafiee Akbar, Sharifi Farshad, Esfahani Morteza Abdar, Badamchizade Zohre, Alatab Sudabeh, Fakhrzadeh Hossein
Elderly Health Research Center, Endocrinology and Metabolism population Sciences Institute, Tehran University of Medical Sciences, North Karegar Avenue, Dr Shariati Hospital, 5th floor, Tehran 1411413137, Iran.
J Diabetes Metab Disord. 2013 Dec 20;12(1):55. doi: 10.1186/2251-6581-12-55.
Diabetic patients are at the risk of cardiac autonomic neuropathy (CAN) and arterial stiffness. This study aimed to investigate the association of heart rate variability (HRV) as an index for CAN and pulse wave velocity (PWV) as an index for arterial stiffness.
Uncomplicated diabetes type-2 patients who had no apparent history of cardiovascular condition underwent HRV and PWV measurements and the results were compared with the control group consisting of non-diabetic peers. Also, the findings were adjusted for the cardiovascular risk factors and other confounding factors.
A total of 64 diabetic patients (age= 52.08±8.50 years; males=33 [51.6%]) were compared with 57 controls (age= 48.74±6.18 years; males=25 [43.9%]) in this study. Hypertension, dyslipidemia, and thereby systolic blood pressure and statin use were significantly more frequent in the diabetic group, while the serum levels of cholesterol, HDL-C and LDL-C were significantly higher in the controls. Pulse wave was significantly increased in the diabetic patients (p<0.001). Main HRV parameters were significantly lower in diabetics than in controls. After adjustment for the confounders, PWV and HRV remained significantly different between the groups (p=0.01 and p=0.004, respectively). Multiple logistic regression of the association between pulse wave velocity and HRV index was independently significant both in diabetics and controls.
There exists a significant relationship between heart rate variability and arterial stiffness as a measure for atherosclerosis in diabetic patients, although the role of the confounding factors is noteworthy.
糖尿病患者存在心脏自主神经病变（CAN）和动脉僵硬度增加的风险。本研究旨在探讨作为CAN指标的心率变异性（HRV）与作为动脉僵硬度指标的脉搏波速度（PWV）之间的关联。
对无明显心血管疾病史的2型糖尿病患者进行HRV和PWV测量，并将结果与由非糖尿病同龄人组成的对照组进行比较。此外，对心血管危险因素和其他混杂因素进行了校正。
本研究共纳入64例糖尿病患者（年龄=52.08±8.50岁；男性=33例[51.6%]），与57例对照组（年龄=48.74±6.18岁；男性=25例[43.9%]）进行比较。糖尿病组高血压、血脂异常、收缩压及他汀类药物使用显著更常见，而对照组胆固醇、高密度脂蛋白胆固醇（HDL-C）和低密度脂蛋白胆固醇（LDL-C）血清水平显著更高。糖尿病患者的脉搏波显著增加（p<0.001）。糖尿病患者的主要HRV参数显著低于对照组。校正混杂因素后，两组间PWV和HRV仍有显著差异（分别为p=0.01和p=0.004）。脉搏波速度与HRV指数之间关联的多因素logistic回归在糖尿病患者和对照组中均具有独立显著性。
糖尿病患者中，心率变异性与作为动脉粥样硬化指标的动脉僵硬度之间存在显著关系，尽管混杂因素的作用值得关注。
