Zeng Q, Dong S-Y, Wang M-L, Wang F, Li J-M, Zhao X-L
Health Management Institute, Chinese PLA General Hospital, Beijing, China.
Health Department of Management and Logistic Support Department, General Staff Department of PLA, Beijing, China.
J Hum Hypertens. 2016 Nov;30(11):720-725. doi: 10.1038/jhh.2015.126. Epub 2016 Jan 7.
The SUDOSCAN test was recently developed to detect diabetic autonomic neuropathy early and screen for cardiac autonomic neuropathy (CAN) through assessment of sudomotor function. The aim of this study was to investigate the relationship of cardiac autonomic dysfunction estimated by the SUDOSCAN test with arterial stiffness. A total of 4019 subjects without diabetes or established cardiovascular disease were tested with SUDOSCAN, central systolic blood pressure (cSBP) and brachial-ankle pulse wave velocity (baPWV). Hands mean electrochemical skin conductance (ESC) measured by SUDOSCAN was 70±17 μS, feet mean ESC was 71±16 μS and the CAN risk score was 21±10%. The levels of cSBP and baPWV increased across quartiles of CAN risk score (P for trend <0.001 for all). In spearman correlation analyses, the CAN risk score was positively correlated with cSBP (r=0.391, P<0.001) and baPWV (r=0.305, P<0.001). In multivariable analyses, the values of cSBP and baPWV increased 0.17 mm Hg (P=0.002) and 2.01 cm per second (P=0.010), respectively, when CAN risk score increased 1%. The results were unchanged when stratified by glucose tolerance status. In conclusion, cardiac autonomic dysfunction estimated by sudomotor function was correlated with arterial stiffness independent of conventional factors and glucose tolerance status.
SUDOSCAN检测最近被开发出来，用于早期检测糖尿病自主神经病变，并通过评估汗腺运动功能来筛查心脏自主神经病变（CAN）。本研究的目的是调查通过SUDOSCAN检测评估的心脏自主神经功能障碍与动脉僵硬度之间的关系。共有4019名无糖尿病或已确诊心血管疾病的受试者接受了SUDOSCAN、中心收缩压（cSBP）和臂踝脉搏波速度（baPWV）检测。SUDOSCAN测量的手部平均电化学皮肤传导率（ESC）为70±17μS，足部平均ESC为71±16μS，CAN风险评分为21±10%。cSBP和baPWV水平随着CAN风险评分四分位数的增加而升高（所有趋势的P<0.001）。在Spearman相关性分析中，CAN风险评分与cSBP（r=0.391，P<0.001）和baPWV（r=0.305，P<0.001）呈正相关。在多变量分析中，当CAN风险评分增加1%时，cSBP和baPWV的值分别增加0.17mmHg（P=0.002）和每秒2.01cm（P=0.010）。按糖耐量状态分层时，结果不变。总之，通过汗腺运动功能评估的心脏自主神经功能障碍与动脉僵硬度相关，且独立于传统因素和糖耐量状态。
