身高与心源性猝死风险：社区动脉粥样硬化风险研究和心血管健康研究。
Height and risk of sudden cardiac death: the Atherosclerosis Risk in Communities and Cardiovascular Health studies.
机构信息
Division of Cardiac Electrophysiology, Veteran's Administration Hospitals of Boston, Harvard Medical School, West Roxbury, MA; Center for Human Genetic Research, Massachusetts General Hospital, Harvard Medical School, Boston.
Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis.
出版信息
Ann Epidemiol. 2014 Mar;24(3):174-179.e2. doi: 10.1016/j.annepidem.2013.11.008. Epub 2013 Nov 26.
PURPOSE
Sudden cardiac death (SCD) is an important cause of mortality in the adult population. Height has been associated with cardiac hypertrophy and an increased risk of arrhythmias but also with decreased risk of coronary heart disease, suggesting a complex association with SCD.
METHODS
We examined the association of adult height with the risk of physician-adjudicated SCD in two large population-based cohorts: the Cardiovascular Health Study and the Atherosclerosis Risk in Communities study.
RESULTS
Over an average follow-up time of 11.7 years in Cardiovascular Health Study, there were 199 (3.6%) cases of SCD among 5556 participants. In Atherosclerosis Risk in Communities study, over 12.6 years, there were 227 (1.5%) cases of SCD among 15,633 participants. In both cohorts, there was a trend toward decreased SCD with taller height. In fixed effects meta-analysis, the pooled hazard ratio per 10 cm of height was 0.84; 95% confidence interval, 0.73-0.98; P = .03. The association of increased height with lower risk of SCD was slightly attenuated after inclusion of risk factors associated with height, such as hypertension and left ventricular hypertrophy. The association appeared stronger among men than women in both cohorts.
CONCLUSIONS
In two population-based prospective cohorts of different ages, greater height was associated with lower risk of SCD.
目的
心源性猝死（SCD）是成年人死亡的重要原因。身高与心脏肥大和心律失常风险增加有关，但也与冠心病风险降低有关，这表明身高与 SCD 之间存在复杂的关联。
方法
我们在两项基于人群的大型队列研究中（心血管健康研究和社区动脉粥样硬化风险研究），研究了成年身高与经医生判断的 SCD 风险之间的关系。
结果
在心血管健康研究中，平均随访时间为 11.7 年，5556 名参与者中有 199 例（3.6%）发生 SCD。在社区动脉粥样硬化风险研究中，在 12.6 年的随访中，15633 名参与者中有 227 例（1.5%）发生 SCD。在两个队列中，身高较高的 SCD 风险呈下降趋势。在固定效应荟萃分析中，身高每增加 10 厘米，风险比为 0.84；95%置信区间为 0.73-0.98；P =.03。在纳入与身高相关的风险因素（如高血压和左心室肥大）后，身高增加与 SCD 风险降低的关联略有减弱。在两个队列中，身高与 SCD 风险降低的关联在男性中比女性更强。
结论
在两个不同年龄的基于人群的前瞻性队列中，较高的身高与较低的 SCD 风险相关。
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