Golmohammadzadeh Shiva, Jaafari Mahmoud Reza, Hosseinzadeh Hossein
Nanotechnology Research Center.
Biotechnology Research Center.
Iran J Pharm Res. 2010 Spring;9(2):133-40.
The objective of this study was to investigate the effects of saffron as a natural sunscreen and moisturizer. The pollens of the saffron were dried and powdered in a grinder. The experimental formulations included a homosalate (8%) lotion reference, lotions with 2, 4 and 8% of grinded saffron, and the control lotion base without saffron. The lotions containing saffron were prepared like homosalate lotion reference according to FDA. The sun protection factors (SPFs) of the formulations were determined by an in vitro spectrophotometry method. The moisture contents of the skin before application and after 30 min and 3, 5 and 7 h post-application of the formulations were measured in human volunteers using Corneometer. The results indicated that, there was no significant difference between the SPF values of the 4% saffron lotion and the homosalate lotion reference. However, the SPF of 8% saffron lotion was significantly more than that of homosalate lotion reference. These results showed that in equal concentrations saffron lotion could act as a better antisolar agent compared to homosalate. Furthermore, there were no significant differences in skin moisture saffron lotions and the control lotion without saffron during the 7 h post-application period. Saffron can be used as a natural UV absorbing agent. The 4% saffron lotion showed an SPF value equivalent to the 8% homosalate lotion reference by an in vitro method. There were no significant differences of skin moisture contents after application of the saffron lotions and the control base lotion without saffron.
本研究的目的是调查藏红花作为天然防晒剂和保湿剂的效果。将藏红花花粉在研磨机中干燥并磨成粉末。实验配方包括一种胡莫柳酯(8%)乳液对照品、含2%、4%和8%研磨藏红花的乳液,以及不含藏红花的对照乳液基质。含藏红花的乳液按照美国食品药品监督管理局(FDA)的标准,参照胡莫柳酯乳液对照品进行制备。通过体外分光光度法测定配方的防晒系数(SPF)。使用皮肤角质层水合测定仪在人类志愿者身上测量涂抹配方前、涂抹后30分钟以及涂抹后3、5和7小时皮肤的水分含量。结果表明,4%藏红花乳液的SPF值与胡莫柳酯乳液对照品之间没有显著差异。然而,8%藏红花乳液的SPF值显著高于胡莫柳酯乳液对照品。这些结果表明,在相同浓度下,藏红花乳液作为防晒剂的效果优于胡莫柳酯。此外,在涂抹后7小时内,含藏红花的乳液与不含藏红花的对照乳液在皮肤水分方面没有显著差异。藏红花可作为天然紫外线吸收剂。通过体外方法,4%藏红花乳液的SPF值与8%胡莫柳酯乳液对照品相当。涂抹藏红花乳液和不含藏红花的对照基础乳液后,皮肤水分含量没有显著差异。