Wang Jianfeng, Meng Hailin, Xiong Zhiqiang, Wang Yong
Key Laboratory of Synthetic Biology, Institute of Plant Physiology and Ecology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200032, China.
Sheng Wu Gong Cheng Xue Bao. 2013 Aug;29(8):1146-60.
Natural products (NPs) are important drug pools for human disease prevention and treatment. The great advances in synthetic biology have greatly revolutionized the strategies of NPs development and production. This review entitled with design and construction of artificial biological systems for complex NPs biosynthesis, mainly introduced the progresses in artificial design of synthetic biological parts, naturally mining novel synthetic parts of NPs, the assembly & adaption of the artificial biological modules & systems.
天然产物是人类疾病预防和治疗的重要药物来源。合成生物学的巨大进展极大地革新了天然产物开发和生产的策略。这篇题为“用于复杂天然产物生物合成的人工生物系统的设计与构建”的综述，主要介绍了合成生物学元件人工设计、天然产物新合成元件的挖掘、人工生物模块与系统的组装及适配等方面的进展。
