Yasumoto R, Kobayakawa H, Asakawa M
Hinyokika Kiyo. 1986 Oct;32(10):1471-3.
The present study was under taken to evaluate the penetration of enoxacin into prostatic tissue. Ten patients with benign prostatic hypertrophy entered the study. Enoxacin was administered orally at a dose of 200 mg, three times one day before and twice on the day of operation. Blood and urine samples were taken 30 min before operation and prostatic tissue samples were taken during operation. The mean concentration of enoxacin was 4.87 +/- 1.39 micrograms/ml in serum and 5.81 +/- 2.95 micrograms/g in the prostatic tissue. The mean ratio of the prostatic concentration/serum concentration was 1.21 +/- 0.63 (range 0.82-3.00).
本研究旨在评估依诺沙星在前列腺组织中的渗透情况。10例良性前列腺增生患者进入该研究。依诺沙星在手术前一天口服给药，剂量为200mg，每日三次，手术当天每日两次。在手术前30分钟采集血液和尿液样本，在手术期间采集前列腺组织样本。依诺沙星在血清中的平均浓度为4.87±1.39微克/毫升，在前列腺组织中的平均浓度为5.81±2.95微克/克。前列腺浓度与血清浓度的平均比值为1.21±0.63（范围为0.82 - 3.00）。
