系统研究不同胞嘧啶修饰物对 CpG 二核苷酸序列的影响：对 B-Z 转变的影响。
Systematic investigations of different cytosine modifications on CpG dinucleotide sequences: the effects on the B-Z transition.
机构信息
College of Chemistry and Molecular Sciences, Key Laboratory of Biomedical Polymers of Ministry of Education, Wuhan University , Wuhan, Hubei 430072, P. R. China.
出版信息
J Am Chem Soc. 2014 Jan 8;136(1):56-9. doi: 10.1021/ja4107012. Epub 2013 Dec 27.
PMID:24364741
Abstract
We have first demonstrated the distinctive effects of three newly reported epigenetic modifications, including 5hmC, 5fC, and 5caC, on B-Z transition of CpG dinucleotide DNAs. We have performed detailed assays and compared their effects. We further studied the regulation of B-Z transition of CpG dinucleotide dodecamers by alternating oxidation and alternating reduction.
摘要
我们首次证明了三种新报道的表观遗传修饰，包括 5hmC、5fC 和 5caC，对 CpG 二核苷酸 DNA 的 B-Z 转变的独特影响。我们进行了详细的检测并比较了它们的影响。我们进一步研究了交替氧化和还原对 CpG 二核苷酸十二聚体 B-Z 转变的调控。
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