College of Chemistry and Molecular Sciences, Key Laboratory of Biomedical Polymers of Ministry of Education, Wuhan University , Wuhan, Hubei 430072, P. R. China.
J Am Chem Soc. 2014 Jan 8;136(1):56-9. doi: 10.1021/ja4107012. Epub 2013 Dec 27.
We have first demonstrated the distinctive effects of three newly reported epigenetic modifications, including 5hmC, 5fC, and 5caC, on B-Z transition of CpG dinucleotide DNAs. We have performed detailed assays and compared their effects. We further studied the regulation of B-Z transition of CpG dinucleotide dodecamers by alternating oxidation and alternating reduction.
我们首次证明了三种新报道的表观遗传修饰，包括 5hmC、5fC 和 5caC，对 CpG 二核苷酸 DNA 的 B-Z 转变的独特影响。我们进行了详细的检测并比较了它们的影响。我们进一步研究了交替氧化和还原对 CpG 二核苷酸十二聚体 B-Z 转变的调控。
