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镨促进自组装DNA纳米结构中的B-Z转变。

Praseodymium promotes B-Z transition in self-assembled DNA nanostructures.

作者信息

Bhanjadeo Madhabi M, Subudhi Umakanta

机构信息

DNA Nanotechnology & Application Laboratory, CSIR-Institute of Minerals & Materials Technology Bhubaneswar 751 013 India

Academy of Scientific & Innovative Research (AcSIR) New Delhi 110025 India.

出版信息

RSC Adv. 2019 Feb 6;9(8):4616-4620. doi: 10.1039/c8ra10164g. eCollection 2019 Jan 30.

DOI:10.1039/c8ra10164g
PMID:35520195
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9060621/
Abstract

Millimolar concentrations of PrCl can induce sequence-specific B-Z transition in various-self-assembled branched DNA (bDNA) nanostructures. Competitive dye binding and thermal kinetics suggest that the phosphate backbone and grooves of bDNA are wrapped with Pr for stabilizing the Z-bDNA. Application of EDTA can convert Z-DNA back to the B-form.

摘要

毫摩尔浓度的氯化镨可在各种自组装分支DNA(bDNA)纳米结构中诱导序列特异性的B-Z转变。竞争性染料结合和热动力学表明,bDNA的磷酸骨架和凹槽被镨包裹,以稳定Z型bDNA。加入乙二胺四乙酸(EDTA)可使Z-DNA转变回B型。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f21a/9060621/decd676678cb/c8ra10164g-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f21a/9060621/19daded58e41/c8ra10164g-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f21a/9060621/3524b2ef1866/c8ra10164g-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f21a/9060621/c6dbb1cb9181/c8ra10164g-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f21a/9060621/decd676678cb/c8ra10164g-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f21a/9060621/19daded58e41/c8ra10164g-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f21a/9060621/3524b2ef1866/c8ra10164g-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f21a/9060621/c6dbb1cb9181/c8ra10164g-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f21a/9060621/decd676678cb/c8ra10164g-f4.jpg

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