镨促进自组装DNA纳米结构中的B-Z转变。

Bhanjadeo Madhabi M, Subudhi Umakanta

DNA Nanotechnology & Application Laboratory, CSIR-Institute of Minerals & Materials Technology Bhubaneswar 751 013 India

Academy of Scientific & Innovative Research (AcSIR) New Delhi 110025 India.

RSC Adv. 2019 Feb 6;9(8):4616-4620. doi: 10.1039/c8ra10164g. eCollection 2019 Jan 30.

Millimolar concentrations of PrCl can induce sequence-specific B-Z transition in various-self-assembled branched DNA (bDNA) nanostructures. Competitive dye binding and thermal kinetics suggest that the phosphate backbone and grooves of bDNA are wrapped with Pr for stabilizing the Z-bDNA. Application of EDTA can convert Z-DNA back to the B-form.

毫摩尔浓度的氯化镨可在各种自组装分支DNA（bDNA）纳米结构中诱导序列特异性的B-Z转变。竞争性染料结合和热动力学表明，bDNA的磷酸骨架和凹槽被镨包裹，以稳定Z型bDNA。加入乙二胺四乙酸（EDTA）可使Z-DNA转变回B型。