Mater Sci Eng C Mater Biol Appl. 2012 Aug 1;32(6):1401-6. doi: 10.1016/j.msec.2012.04.016. Epub 2012 Apr 20.
A series of Ga-containing phospho-silicate glasses based on Bioglass 45S5, having molar formula 46.2SiO2·24.3Na2O·26.9CaO·2.6P2O5·xGa2O3 (x=1.0, 1.6, 3.5), were prepared by fusion method. The reference Bioglass 45S5 without gallium was also prepared. The synthesized glasses were immersed in simulated body fluid (SBF) for 30 days in order to observe ion release and hydroxyapatite (HA) formation. All Ga-containing glasses maintain the ability of HA formation as indicated by main X-ray diffractometric peaks and/or electronic scanning microscopy results. HA layer was formed after 1 day of SBF soaking in 45S5 glass containing up to 1.6% Ga2O3 content. Moreover, gallium released by the glasses was found to be partially precipitated on the glass surface as gallium phosphate. Further increase in gallium content reduced the ion release in SBF. The maximum of Ga(3+) concentration measured in solution is ~6 ppm determined for 3.5% Ga2O3 content. This amount is about half of the toxic level (14 ppm) of gallium and the glasses release gallium till 30 days of immersion in SBF. Considering the above results, the studied materials can be proposed as bioactive glasses with additional antimicrobial effect of gallium having no toxic outcome.
一系列基于 Bioglass 45S5 的含 Ga 磷硅酸盐玻璃，具有摩尔配方 46.2SiO2·24.3Na2O·26.9CaO·2.6P2O5·xGa2O3（x=1.0、1.6、3.5），采用熔融法制备。还制备了不含 Ga 的参考 Bioglass 45S5。将合成的玻璃在模拟体液（SBF）中浸泡 30 天，以观察离子释放和羟基磷灰石（HA）形成。所有含 Ga 的玻璃都保持形成 HA 的能力，这表明主要 X 射线衍射峰和/或电子扫描显微镜结果。在含有高达 1.6% Ga2O3 的 45S5 玻璃中，在 SBF 浸泡 1 天后就形成了 HA 层。此外，玻璃释放的 Ga 被发现部分以磷酸 Ga 的形式沉淀在玻璃表面。Ga 含量的进一步增加会降低 SBF 中的离子释放。在溶液中测量的 Ga(3+)浓度的最大值约为~6 ppm，Ga2O3 含量为 3.5%。这个数量约为 Ga 毒性水平（14 ppm）的一半，并且玻璃在 SBF 浸泡 30 天后仍会释放 Ga。考虑到上述结果，研究材料可被提议为具有抗菌作用的生物活性玻璃，同时 Ga 具有无毒性的额外效果。
