Institute for Orthopaedics Sports Medicine and Rehabilitation University of Iowa Iowa City, Iowa.
Clin J Sport Med. 2014 Jan;24(1):90-1. doi: 10.1097/JSM.0000000000000064.
To compare the outcomes (reruptures and other complications, strength, and return to work) of open surgical repair of acute Achilles tendon ruptures with nonoperative management, by means of a meta-analysis of the results of randomized controlled trials (RCTs).
The online search using words related to management of Achilles tendon rupture included MEDLINE, PubMed, the Cochrane Database of Systematic Reviews, and the American College of Physicians Journal Club. Reference lists of relevant articles were searched for further studies.
Inclusion criteria were RCTs, published in English, that compared open surgery with nonoperative management of acute Achilles tendon ruptures, and that reported the rate of reruptures as an outcome. Of 1163 articles identified, 44 were read in full, and 7 met inclusion criteria.
Data on samples, management of the rupture, outcomes, and length of follow-up were extracted. The methods of the trials were assessed using the 10 criteria of the Coleman methodology score.
Among patients followed for 10 to 36 months, the pooled rate of tendon reruptures was lower in those treated surgically, 3.6% (n = 15), compared with 8.8% (n = 38) for patients managed nonoperatively (odds ratio [OR] favoring open surgical repair, 0.425; 95% confidence interval [CI], 0.222-0.815). Other complications were mostly higher in the open surgery group. In 5 studies reporting deep infection rates, there were none in the nonsurgically managed group versus 6 in 254 patients (2.36%) among the open surgery patients (P = 0.0113). In 6 studies reporting noncosmetic scar complaints, the pooled rate was 13.1% for patients treated with surgery and 0.62% for patients treated nonoperatively (P < 0.001). In 5 studies reporting sural nerve sensory disturbances, the pooled rate was 8.76% of surgical patients compared with 0.78% of patients treated nonoperatively (P < 0.001). In 4 studies, the pooled rate of deep vein thrombosis did not differ significantly between the surgery group (7.08%) and the nonoperative group (10.24%; P = 0.1706). Time to return to work after the beginning of treatment did not differ between groups (pooled mean difference favoring surgical management, 7.453 days; 95% CI, -4.959 to 19.864) in 4 studies. Measurements of strength were too heterogeneous to be pooled. The mean age of the 677 patients was approximately 40 years, and ≥70% of each group was male.
Rates of reruptures after open surgical treatment of acute Achilles tendon ruptures were lower than those among patients managed nonsurgically. However, the rates of complications of surgery, such as deep infections, noncosmetic scarring, and sural nerve disturbances, should cause concern.
通过荟萃分析随机对照试验(RCT)的结果,比较急性跟腱断裂的开放性手术修复与非手术治疗的结局(再断裂和其他并发症、强度和恢复工作)。
使用与跟腱断裂管理相关的词进行在线检索,包括 MEDLINE、PubMed、Cochrane 系统评价数据库和美国医师学会杂志俱乐部。进一步研究的相关文章的参考文献也被检索到。
纳入标准为 RCT,发表于英文期刊,比较急性跟腱断裂的开放性手术与非手术治疗,且将再断裂率作为结局进行报告。在确定的 1163 篇文章中,有 44 篇文章进行了全文阅读,其中 7 篇符合纳入标准。
提取样本、断裂管理、结局和随访时间的数据。使用 Coleman 方法学评分的 10 项标准评估试验方法。
在随访 10 至 36 个月的患者中,手术治疗组的肌腱再断裂率为 3.6%(n=15),低于非手术治疗组的 8.8%(n=38)(有利于开放手术修复的比值比,0.425;95%置信区间,0.222-0.815)。手术组的其他并发症大多较高。在 5 项报告深部感染率的研究中,非手术治疗组无感染,而在 254 例手术治疗组中,有 6 例(2.36%)(P=0.0113)。在 6 项报告非美容性瘢痕投诉的研究中,手术治疗组的总体率为 13.1%,而非手术治疗组为 0.62%(P<0.001)。在 5 项报告腓肠神经感觉障碍的研究中,手术组的总体率为 8.76%,而非手术组为 0.78%(P<0.001)。在 4 项研究中,手术组和非手术组的深静脉血栓形成发生率无显著差异(分别为 7.08%和 10.24%;P=0.1706)。在 4 项研究中,从治疗开始到恢复工作的时间在手术组(7.453 天;95%置信区间,4.959-19.864)和非手术组(7.453 天;95%置信区间,4.959-19.864)之间无显著差异(有利于手术管理的汇总均数差值)。力量测量的结果差异太大,无法进行汇总。677 例患者的平均年龄约为 40 岁,每组≥70%为男性。
与非手术治疗相比,急性跟腱断裂开放性手术后再断裂的发生率较低。然而,手术相关并发症(如深部感染、非美容性瘢痕形成和腓肠神经损伤)的发生率应该引起关注。