Liu Mu-En, Huang Chu-Chung, Chen Mu-Hong, Yang Albert C, Tu Pei-Chi, Yeh Heng-Liang, Hong Chen-Jee, Chen Jin-Fan, Hwang Jen-Ping, Lin Ching-Po, Tsai Shih-Jen
Department of Psychiatry, Taipei Veterans General Hospital, Taipei, Taiwan.
Neuromolecular Med. 2014 Mar;16(1):127-36. doi: 10.1007/s12017-013-8265-7. Epub 2013 Dec 24.
The brain-derived neurotrophic factor (BDNF) Val66Met polymorphism is common and influences the activity-dependent secretion of BDNF, which is critical for neuronal plasticity and survival. This study investigated the genetic effect of the BDNF Val66Met polymorphism on cognitive function and regional gray matter (GM) volume in a healthy Chinese population (n = 330). Voxel-based morphometry (VBM)-optimized analysis was used. There was no significant difference in the neuropsychological performances among the three BDNF genotypic groups. VBM analyses demonstrated that Met homozygotes had greater GM volumes than Val homozygotes in the left medial frontal gyrus, the left middle temporal gyrus, the left cerebellum, and the right middle temporal gyrus, and had larger GM volumes than Val/Met heterozygotes in the left middle temporal gyrus, the left inferior temporal gyrus, and the right superior frontal gyrus. Our findings suggest that the presence of two Met alleles has a protective effect on regional GM volumes in the Chinese population.
脑源性神经营养因子（BDNF）Val66Met多态性很常见，且会影响BDNF的活性依赖性分泌，而BDNF的活性依赖性分泌对神经元可塑性和存活至关重要。本研究调查了BDNF Val66Met多态性对中国健康人群（n = 330）认知功能和局部灰质（GM）体积的遗传效应。采用了基于体素的形态学测量（VBM）优化分析。在三个BDNF基因型组之间，神经心理学表现没有显著差异。VBM分析表明，Met纯合子在左侧额内侧回、左侧颞中回、左侧小脑和右侧颞中回的GM体积大于Val纯合子，在左侧颞中回、左侧颞下回和右侧额上回的GM体积大于Val/Met杂合子。我们的研究结果表明，两个Met等位基因的存在对中国人群的局部GM体积具有保护作用。
