Department of Psychosis Studies, Institute of Psychiatry, King's College London, De Crespigny Park, London SE5 8AF, UK.
Neurosci Biobehav Rev. 2012 Oct;36(9):2165-77. doi: 10.1016/j.neubiorev.2012.07.002. Epub 2012 Jul 16.
Brain derived neurotrophic factor (BDNF) is a critical component of the molecular mechanism of memory formation. Variation in the BDNF gene, particularly the rs6265 (val(66)met) single nucleotide polymorphism (SNP), has been linked to variability in human memory performance and to both the structure and physiological response of the hippocampus, which plays a central role in memory processing. However, these effects have not been consistently reported, which may reflect the modest size of the samples studied to date. Employing a meta-analytic approach, we examined the effect of the BDNF val(66)met polymorphism on human memory (5922 subjects) and hippocampal structure (2985 subjects) and physiology (362 subjects). Our results suggest that variations in the rs6265 SNP of the BDNF gene have a significant effect on memory performance, and on both the structure and physiology of the hippocampus, with carriers of the met allele being adversely affected. These results underscore the role of BDNF in moderating variability between individuals in human memory performance and in mediating some of the neurocognitive impairments underlying neuropsychiatric disorders.
脑源性神经营养因子（BDNF）是记忆形成的分子机制的关键组成部分。BDNF 基因的变异，特别是 rs6265（val(66)met）单核苷酸多态性（SNP），与人类记忆表现的可变性以及海马体的结构和生理反应有关，海马体在记忆处理中起着核心作用。然而，这些效应并没有得到一致的报道，这可能反映了迄今为止研究样本的规模较小。我们采用荟萃分析的方法，研究了 BDNF val(66)met 多态性对人类记忆（5922 名受试者）和海马体结构（2985 名受试者）和生理学（362 名受试者）的影响。我们的结果表明，BDNF 基因的 rs6265 SNP 变异对记忆表现以及海马体的结构和生理学有显著影响，携带 met 等位基因的个体受到不利影响。这些结果强调了 BDNF 在调节个体间人类记忆表现的变异性以及介导神经精神障碍下一些神经认知障碍中的作用。
