Department of Gastroenterology and Hepatology, The Jikei University School of Medicine, Tokyo, Japan .
Proc Jpn Acad Ser B Phys Biol Sci. 2007 Dec;83(8):248-55. doi: 10.2183/pjab/83.248.
This review focuses on our basic study results and clinical experience of fluorescence endoscopy for the gastrointestinal (GI) tract. Collagen, which fluoresces in the green wavelength range, is one of the major sources of tissue autofluorescence (AF) and AF imaging systems are now available. With their use, however, it is important to take into account tissue changes other than, or in addition to, changes in gross tissue morphology. These may include alterations in the local blood volume, tissue metabolic activity, and relative fluorophore concentrations. New AF imaging systems are very easy to use, because white light endoscopy can be changed to AF at the push of a button, and hold great promise for diagnosis of early carcinomas and premalignant lesions in the GI tract. In particular, AF endoscopy has potential for identification of small or flat tumors, tumor margins and premalignant lesions in Barrett's esophagus, as well as for assessing tumor grade and response to therapy. However, large-scale studies are needed to clarify the clinical impact of this new diagnostic approach.
本文重点介绍了我们在胃肠道荧光内镜方面的基础研究结果和临床经验。 胶原蛋白在绿光波长范围内发出荧光，是组织自发荧光（AF）的主要来源之一，目前已经有 AF 成像系统。 然而，在使用这些系统时，除了组织大体形态的变化外，还必须考虑到其他组织变化。 这些变化可能包括局部血容量、组织代谢活性和相对荧光浓度的改变。 新型 AF 成像系统非常易于使用，因为只需按下按钮即可将白光内镜切换为 AF 模式，并且在诊断胃肠道早期癌和癌前病变方面具有很大的应用前景。 特别是，AF 内镜在识别小或扁平肿瘤、肿瘤边缘和 Barrett 食管中的癌前病变、评估肿瘤分级以及对治疗的反应方面具有潜在作用。 然而，需要进行大规模研究来阐明这种新诊断方法的临床意义。
