Department of General Surgery, Government Medical College, Miraj, Maharashtra, India.
Department of General Surgery, DY Patil Hospital and Research Centre, Nerul, Navi Mumbai, India.
Breast Cancer (Dove Med Press). 2011 Apr 19;3:27-33. doi: 10.2147/BCTT.S17892. eCollection 2011.
To determine the expressions and relationship between estrogen receptors (ERs) and progesterone receptors (PgRs) in breast cancer in Indian women.
Surgically removed breast cancer tissues were collected from Grant Medical College and Sir JJ Group of Hospitals, Mumbai, India, taking (n = 300) cases of infiltrating duct cancer of Indian women after radical mastectomy and lumpectomy; the age- and menopausal-related subgroups satisfied this requirement.
Statistical significance was calculated by the likelihood ratio test; relative risk served to check for significant differences. Relapse-free interval probabilities were calculated according to Kaplan and Meier, with Cox-Mantel test comparing survival functions and P values.
We observed that only in middle-aged postmenopausal patients bearing pT2 tumors were ER and PgR receptors shown to have a prognostic significance with the lowest tested cutoff value being 5 fmol/mg.
Immunohistochemistry analysis has been shown to be a prognostic factor for patients with breast cancer; the major aim of determining the ER receptor status is to assess predictive response to hormonal therapy.
确定印度女性乳腺癌中雌激素受体（ER）和孕激素受体（PgR）的表达和关系。
从印度孟买格兰特医学院和 Sir JJ 集团医院采集了手术切除的乳腺癌组织，共纳入 300 例接受根治性乳房切除术和肿瘤切除术的印度女性浸润性导管癌病例；年龄和绝经相关亚组符合这一要求。
通过似然比检验计算统计学意义；相对风险用于检查显著差异。根据 Kaplan 和 Meier 计算无复发生存概率，采用 Cox-Mantel 检验比较生存函数和 P 值。
我们观察到，只有在中年绝经后患者中，pT2 肿瘤的 ER 和 PgR 受体显示出具有预后意义的最低检测截值为 5 fmol/mg。
免疫组织化学分析已被证明是乳腺癌患者的预后因素；确定 ER 受体状态的主要目的是评估对激素治疗的预测反应。
