Sears H F, Janus C, Levy W, Hopson R, Creech R, Grotzinger P
Cancer. 1982 Nov 1;50(9):1820-7. doi: 10.1002/1097-0142(19821101)50:9<1820::aid-cncr2820500928>3.0.co;2-s.
Two hundred seventy-five patients with breast cancer and no axillary metastases had mastectomies and axillary node dissection performed during the period between 1970 and 1979 at The Fox Chase Cancer Center. They had a mean age of 60 years (range, 21-91) and 38 (14%) patients have had recurrence to date. Poor histologic differentiation and skin involvement were related to a high risk of recurrence. Those patients with skin infiltration by tumor or a poorly differentiated tumor had a 53 +/- 9% expected five-year tumor-free survival, whereas patients without these had a 90 +/- 2% expected five-year tumor-free survival. Tumor involvement of the lymphatic vessels within the breast and estrogen receptor protein positivity or negativity were not helpful for identifying a subpopulation at increased risk of recurrence. Large tumor size was not a poor prognostic indicator for a patient subpopulation. These factors should be considered as indicators for inclusion in clinical trials and adjuvant therapy and used as stratification points for the analysis of the data developed in these trials.
1970年至1979年期间，275例无腋窝转移的乳腺癌患者在福克斯蔡斯癌症中心接受了乳房切除术和腋窝淋巴结清扫术。他们的平均年龄为60岁（范围21 - 91岁），迄今为止有38例（14%）患者出现复发。组织学分化差和皮肤受累与高复发风险相关。肿瘤浸润皮肤或肿瘤分化差的患者预期五年无瘤生存率为53±9%，而无这些情况的患者预期五年无瘤生存率为90±2%。乳腺内淋巴管的肿瘤累及以及雌激素受体蛋白阳性或阴性对识别复发风险增加的亚组人群并无帮助。肿瘤体积大并非患者亚组人群的不良预后指标。这些因素应被视为纳入临床试验和辅助治疗的指标，并用作这些试验所产生数据分析的分层点。
