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Stressing the importance of CHOP in liver cancer.

作者信息

Updegraff Barrett L, O'Donnell Kathryn A

机构信息

Department of Molecular Biology, UT Southwestern Medical Center, Dallas, Texas, United States of America.

出版信息

PLoS Genet. 2013;9(12):e1004045. doi: 10.1371/journal.pgen.1004045. Epub 2013 Dec 19.

DOI:10.1371/journal.pgen.1004045
PMID:24367283
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3868558/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bcb2/3868558/fdb72191dcf3/pgen.1004045.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bcb2/3868558/fdb72191dcf3/pgen.1004045.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bcb2/3868558/fdb72191dcf3/pgen.1004045.g001.jpg

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本文引用的文献

1
The stress-regulated transcription factor CHOP promotes hepatic inflammatory gene expression, fibrosis, and oncogenesis.应激调节转录因子 CHOP 促进肝脏炎症基因表达、纤维化和肿瘤发生。
PLoS Genet. 2013;9(12):e1003937. doi: 10.1371/journal.pgen.1003937. Epub 2013 Dec 19.
2
Identification of rtl1, a retrotransposon-derived imprinted gene, as a novel driver of hepatocarcinogenesis.鉴定 rtl1 为一种新型肝癌发生的反转录转座子衍生的印记基因驱动子。
PLoS Genet. 2013 Apr;9(4):e1003441. doi: 10.1371/journal.pgen.1003441. Epub 2013 Apr 4.
3
A Sleeping Beauty mutagenesis screen reveals a tumor suppressor role for Ncoa2/Src-2 in liver cancer.
长链非编码RNA HOXA-AS2通过表观遗传沉默P21/PLK3/DDIT3表达促进胃癌增殖。
Oncotarget. 2015 Oct 20;6(32):33587-601. doi: 10.18632/oncotarget.5599.
一项沉睡美人突变体筛选实验揭示了 Ncoa2/Src-2 在肝癌中作为肿瘤抑制因子的作用。
Proc Natl Acad Sci U S A. 2012 May 22;109(21):E1377-86. doi: 10.1073/pnas.1115433109. Epub 2012 May 3.
4
The unfolded protein response: from stress pathway to homeostatic regulation.未折叠蛋白反应：从应激途径到动态平衡调节。
Science. 2011 Nov 25;334(6059):1081-6. doi: 10.1126/science.1209038.
5
Regulation of basal cellular physiology by the homeostatic unfolded protein response.通过细胞内未折叠蛋白反应的稳态调节来控制基础细胞生理机能。
J Cell Biol. 2010 May 31;189(5):783-94. doi: 10.1083/jcb.201003138.
6
PERK promotes cancer cell proliferation and tumor growth by limiting oxidative DNA damage.PERK 通过限制氧化 DNA 损伤促进癌细胞增殖和肿瘤生长。
Oncogene. 2010 Jul 8;29(27):3881-95. doi: 10.1038/onc.2010.153. Epub 2010 May 10.
7
Nonalcoholic fatty liver disease and hepatocellular carcinoma: a weighty connection.非酒精性脂肪性肝病与肝细胞癌：沉甸甸的关联。
Hepatology. 2010 May;51(5):1820-32. doi: 10.1002/hep.23594.
8
A modified sleeping beauty transposon system that can be used to model a wide variety of human cancers in mice.一种经过改良的睡美人转座子系统，可用于在小鼠中模拟多种人类癌症。
Cancer Res. 2009 Oct 15;69(20):8150-6. doi: 10.1158/0008-5472.CAN-09-1135. Epub 2009 Oct 6.
9
Principles of cancer therapy: oncogene and non-oncogene addiction.癌症治疗原则：癌基因与非癌基因成瘾
Cell. 2009 Mar 6;136(5):823-37. doi: 10.1016/j.cell.2009.02.024.
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Hepatocellular carcinoma incidence, mortality, and survival trends in the United States from 1975 to 2005.1975年至2005年美国肝细胞癌的发病率、死亡率及生存趋势
J Clin Oncol. 2009 Mar 20;27(9):1485-91. doi: 10.1200/JCO.2008.20.7753. Epub 2009 Feb 17.