Division of Molecular Science, Graduate School of Science and Technology, Gunma University, Tenjin-cho, Kiryu, Gunma 376-8515, Japan.
Department of Synthetic and Biological Chemistry, Graduate School of Engineering, Kyoto University, Nishikyo-ku, Kyoto 615-8510, Japan.
Beilstein J Org Chem. 2013 Dec 5;9:2793-802. doi: 10.3762/bjoc.9.314.
Organo-fluorine compounds are the substances of considerable interest in various industrial fields due to their unique physical and chemical properties. Despite increased demand in wide fields of science, synthesis of fluoro-organic compounds is still often faced with problems such as the difficulties in handling of fluorinating reagents and in controlling of chemical reactions. Recently, flow microreactor synthesis has emerged as a new methodology for producing chemical substances with high efficiency. This review outlines the successful examples of synthesis and reactions of fluorine-containing molecules by the use of flow microreactor systems to overcome long-standing problems in fluorine chemistry.
有机氟化合物因其独特的物理化学性质，在各个工业领域都具有相当大的应用价值。尽管在科学的各个领域对有机氟化合物的需求不断增加，但由于氟试剂的处理和化学反应的控制等问题，有机氟化合物的合成仍然面临着许多挑战。最近，流动微反应器合成作为一种高效生产化学物质的新方法已经出现。本综述概述了使用流动微反应器系统合成和反应含氟分子的成功实例，以克服氟化学中长期存在的问题。
