使用氟仿的气/液相微流三氟甲基化反应：醛、酮、查尔酮和亚磺酰亚胺的三氟甲基化反应

Gas/Liquid-Phase Micro-Flow Trifluoromethylation using Fluoroform: Trifluoromethylation of Aldehydes, Ketones, Chalcones, and -Sulfinylimines.

作者信息

Hirano Kazuki, Gondo Satoshi, Punna Nagender, Tokunaga Etsuko, Shibata Norio

机构信息

Department of Life Science and Applied Chemistry, Department of Nanopharmaceutical Sciences Nagoya Institute of Technology Gokiso, Showa-ku, Nagoya 466-8555 Japan.

Institute of Advanced Fluorine-Containing Materials Zhejiang Normal University 688 Yingbin Avenue 321004 Jinhua China.

出版信息

ChemistryOpen. 2019 Feb 5;8(4):406-410. doi: 10.1002/open.201800286. eCollection 2019 Apr.

A micro-flow nucleophilic trifluoromethylation of carbonyl compounds using gaseous fluoroform was developed. This method also allows the first micro-flow transformation of -sulfinylimines into trifluoromethyl amines with excellent diastereoselectivity. To demonstrate the synthetic utility of this micro-flow synthesis, the formal micro-flow synthesis of Efavirenz is described.