Stahl W M
Crit Care Med. 1987 Jun;15(6):545-50. doi: 10.1097/00003246-198706000-00001.
Macrophages activated at sites of tissue injury produce interleukin-1, which induces hepatocytes to synthesize acute phase proteins (APP). Daily serum levels of C-reactive protein (CRP), haptoglobin (HPT), transferrin (TRF), alpha-1 antitrypsin, and ceruloplasmin (CER) were measured in 60 patients, 30 having inguinal herniorrhaphy (H), 18 cholecystectomy (C), and 12 major abdominal trauma (MAT). APP response was proportional to the level of tissue injury. CRP rose in all groups, MAT greater than C, which was greater than H. HPT levels were depressed in MAT, presumably due to removal of hemoglobin-HPT complexes from the serum. TRF was severely depressed in MAT and may be implicated in the higher infection susceptibility in this group. CER was elevated in C, suggesting a stimulating mechanism in this group as opposed to H and MAT. Explanation for this is unknown. APP changes, especially CRP, may be useful as markers of the amount of tissue damage.
在组织损伤部位被激活的巨噬细胞会产生白细胞介素-1，后者可诱导肝细胞合成急性期蛋白（APP）。对60例患者测定了血清中C反应蛋白（CRP）、触珠蛋白（HPT）、转铁蛋白（TRF）、α1抗胰蛋白酶和铜蓝蛋白（CER）的每日水平，其中30例行腹股沟疝修补术（H），18例行胆囊切除术（C），12例为严重腹部创伤（MAT）。APP反应与组织损伤程度成正比。所有组的CRP均升高，MAT组升高幅度大于C组，C组大于H组。MAT组HPT水平降低，可能是由于血清中血红蛋白-HPT复合物被清除。MAT组TRF严重降低，这可能与该组较高的感染易感性有关。C组CER升高，提示该组存在一种刺激机制，与H组和MAT组不同。其原因尚不清楚。APP变化，尤其是CRP变化，可能有助于作为组织损伤程度的标志物。
