Jackson Michael L, Henrikson Nora B, Grossman David C
Group Health Research Institute, Seattle, Wash.
Group Health Research Institute, Seattle, Wash.
Acad Pediatr. 2014 Jan-Feb;14(1):71-6. doi: 10.1016/j.acap.2013.10.002.
Immunization information systems (IISs) are powerful public health tools for vaccination activities. To date, however, their use for public health research has been limited, in part as a result of insufficient understanding on accuracy and quality of IIS data. We evaluated the completeness and accuracy of Washington State IIS (WAIIS) data, with particular attention to data elements of research interest.
We analyzed all WAIIS records on all children born between 2006 and 2010 with at least 1 vaccination recorded in WAIIS between 2006 and 2010. We assessed all variables for completeness and tested selected variables for internal validity. To assess external validity, we matched WAIIS data to records from Group Health, a large integrated health care organization in Washington State. On these children, we compared vaccination data in WAIIS with vaccination data from Group Health's immunization registry.
The WAIIS data included 486,265 children and 8,670,234 unique vaccinations. Variables required by WAIIS (such as date of vaccination) were highly complete, but optional variables were often missing. For example, most records were missing data on route (80.7%) and anatomic site (81.7%) of vaccination. WAIIS data, when complete, were highly accurate relative to the Group Health immunization registry, with 96% to 99% agreement between fields such as vaccination code and anatomic site.
Required data elements in WAIIS are highly complete and have both internal and external validity, suggesting that these variables are useful for research. Research requiring nonrequired variables should use additional validity checks before proceeding.
免疫信息系统（IISs）是疫苗接种活动强有力的公共卫生工具。然而，迄今为止，它们在公共卫生研究中的应用有限，部分原因是对IIS数据的准确性和质量认识不足。我们评估了华盛顿州免疫信息系统（WAIIS）数据的完整性和准确性，特别关注研究感兴趣的数据元素。
我们分析了2006年至2010年出生且在2006年至2010年期间WAIIS中至少记录了1次疫苗接种的所有儿童的WAIIS记录。我们评估了所有变量的完整性，并对选定变量进行了内部有效性测试。为了评估外部有效性，我们将WAIIS数据与华盛顿州一家大型综合医疗保健机构Group Health的记录进行了匹配。对于这些儿童，我们将WAIIS中的疫苗接种数据与Group Health免疫登记处的疫苗接种数据进行了比较。
WAIIS数据包括486,265名儿童和8,670,234次独特的疫苗接种。WAIIS要求的变量（如接种日期）非常完整，但可选变量经常缺失。例如，大多数记录缺少接种途径（80.7%）和接种解剖部位（81.7%）的数据。与Group Health免疫登记处相比，WAIIS数据完整时具有高度准确性，疫苗接种代码和解剖部位等字段之间的一致性为96%至99%。
WAIIS中要求的数据元素非常完整，具有内部和外部有效性，表明这些变量对研究有用。需要非必需变量的研究在进行之前应使用额外的有效性检查。
