Public Health Microbiology, Communicable Disease, Queensland Health Forensic and Scientific Services, Archerfield Queensland 4108, Australia.
Public Health Microbiology, Communicable Disease, Queensland Health Forensic and Scientific Services, Archerfield Queensland 4108, Australia.
Diagn Microbiol Infect Dis. 2014 Mar;78(3):307-12. doi: 10.1016/j.diagmicrobio.2013.11.017. Epub 2013 Nov 27.
Streptococcus pneumoniae serotype 6C was first identified in 2007, although retrospective studies have since identified serotype 6C among stored isolates dating back to 1962. We investigated the incidence and genetic diversity of serotype 6C strains isolated from Queensland patients between 2001 and 2011. Isolates were identified by Quellung reaction and antimicrobial susceptibility testing was performed. The incidence of serotype 6C among serogroup 6 Queensland invasive pneumococcal disease increased from 6.8% (2001-2004) to 39% (2005-2010) of serogroup 6 isolates (P = 0). Genetic diversity of Queensland 6C isolates was high, with molecular analysis identifying 19 sequence types by multi-locus sequence typing, and 35 types by multi-locus variable-number tandem repeat analysis.
肺炎链球菌 6C 血清型于 2007 年首次被鉴定出来，尽管回顾性研究发现，1962 年储存的分离株中就存在 6C 血清型。我们调查了 2001 年至 2011 年间昆士兰州患者分离的 6C 血清型菌株的发病率和遗传多样性。通过胶乳反应鉴定分离株，并进行抗菌药物敏感性试验。血清型 6C 在血清型 6 组昆士兰侵袭性肺炎球菌病中的发病率从 6.8%（2001-2004 年）上升至 39%（2005-2010 年）（P=0.003）。昆士兰 6C 分离株的遗传多样性很高，通过多位点序列分型鉴定出 19 种序列型，通过多位点可变数目串联重复分析鉴定出 35 种类型。
