Reis Mysrayn Y F A, Dos Santos Simone M, Silva Danielle R, Silva Márcia V, Correia Maria Tereza S, Navarro Daniela M A Ferraz, Santos Geanne K N, Hallwass Fernando, Bianchi Otávio, Silva Alexandre G, Melo Janaína V, Mattos Alessandra B, Ximenes Rafael M, Machado Giovanna, Saraiva Karina L A
Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade Estadual da Paraíba, Rua Juvêncio Arruda S/N, Bairro Universitário, 58429-600 Campina Grande, PB, Brazil.
Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade Federal de Pernambuco, Av. Prof. Moraes Rego, No. 1235, Cidade Universitária, 50670-901 Recife, PE, Brazil.
Evid Based Complement Alternat Med. 2017;2017:3647801. doi: 10.1155/2017/3647801. Epub 2017 Dec 21.
Babassu oil extraction is the main income source in nut breakers communities in northeast of Brazil. Among these communities, babassu oil is used for cooking but also medically to treat skin wounds and inflammation, and vulvovaginitis. This study aimed to evaluate the anti-inflammatory activity of babassu oil and develop a microemulsion system with babassu oil for topical delivery. Topical anti-inflammatory activity was evaluated in mice ear edema using PMA, arachidonic acid, ethyl phenylpropiolate, phenol, and capsaicin as phlogistic agents. A microemulsion system was successfully developed using a Span® 80/Kolliphor® EL ratio of 6 : 4 as the surfactant system (S), propylene glycol and water (3 : 1) as the aqueous phase (A), and babassu oil as the oil phase (O), and analyzed through conductivity, SAXS, DSC, TEM, and rheological assays. Babassu oil and lauric acid showed anti-inflammatory activity in mice ear edema, through inhibition of eicosanoid pathway and bioactive amines. The developed formulation (39% A, 12.2% O, and 48.8% S) was classified as a bicontinuous to o/w transition microemulsion that showed a Newtonian profile. The topical anti-inflammatory activity of microemulsified babassu oil was markedly increased. A new delivery system of babassu microemulsion droplet clusters was designed to enhance the therapeutic efficacy of vegetable oil.
巴巴苏油提取是巴西东北部坚果破碎者社区的主要收入来源。在这些社区中，巴巴苏油不仅用于烹饪，还用于医学上治疗皮肤伤口和炎症以及外阴阴道炎。本研究旨在评估巴巴苏油的抗炎活性，并开发一种含巴巴苏油的微乳体系用于局部给药。使用佛波酯、花生四烯酸、苯丙炔酸乙酯、苯酚和辣椒素作为炎症介质，通过小鼠耳部水肿模型评估局部抗炎活性。以6:4的司盘®80/聚氧乙烯蓖麻油EL比例作为表面活性剂体系（S），丙二醇和水（3:1）作为水相（A），巴巴苏油作为油相（O），成功开发了一种微乳体系，并通过电导率、小角X射线散射、差示扫描量热法、透射电子显微镜和流变学分析进行了表征。巴巴苏油和月桂酸通过抑制类花生酸途径和生物活性胺，在小鼠耳部水肿中表现出抗炎活性。所开发的制剂（39%A、12.2%O和48.8%S）被归类为一种从双连续到油包水转变的微乳，呈现牛顿流体特性。微乳化巴巴苏油的局部抗炎活性显著提高。设计了一种新的巴巴苏微乳滴簇递送系统，以提高植物油的治疗效果。
