危重症患者的免疫炎症反应：严重脓毒症和/或创伤。
Immunoinflammatory response in critically ill patients: severe sepsis and/or trauma.
机构信息
Clinic of Anesthesiology and Intensive Therapy, Military Medical Academy, Crnotravska 17, 11000 Belgrade, Serbia ; Faculty of Medicine of the Military Medical Academy, University of Defence, Crnotravska 17, 11000 Belgrade, Serbia.
Clinical Center Kragujevac, Zmaj Jovina 30, 34000 Kragujevac, Serbia ; Faculty of Medical Sciences, University of Kragujevac, Svetozara Markovica 69, 34000 Kragujevac, Serbia.
出版信息
Mediators Inflamm. 2013;2013:362793. doi: 10.1155/2013/362793. Epub 2013 Nov 24.
Abstract
Immunoinflammatory response in critically ill patients is very complex. This review explores some of the new elements of immunoinflammatory response in severe sepsis, tumor necrosis factor-alpha in severe acute pancreatitis as a clinical example of immune response in sepsis, immune response in severe trauma with or without secondary sepsis, and genetic aspects of host immuno-inflammatory response to various insults in critically ill patients.
摘要
危重病患者的免疫炎症反应非常复杂。本综述探讨了严重脓毒症中免疫炎症反应的一些新元素、作为脓毒症免疫反应临床范例的严重急性胰腺炎中的肿瘤坏死因子-α、伴或不伴继发脓毒症的严重创伤的免疫反应，以及宿主对危重病患者各种损伤的免疫炎症反应的遗传方面。
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2
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