Zivkovic Aleksandar R, Schmidt Karsten, Hofer Stefan, Brenner Thorsten, Weigand Markus A, Decker Sebastian O
Department of Anesthesiology, Heidelberg University Hospital, 69120 Heidelberg, Germany.
Department of Anesthesiology and Intensive Care Medicine, University Hospital Essen, University Duisburg-Essen, 45147 Essen, Germany.
Biomedicines. 2023 Jul 26;11(8):2111. doi: 10.3390/biomedicines11082111.
(1) Background: Sepsis is a severe systemic inflammatory condition characterized by rapid clinical deterioration and organ dysfunction. The cholinergic system has been implicated in modulating the inflammatory response. Acetylcholinesterase (AChE), an enzyme primarily responsible for the hydrolysis of acetylcholine, has been proposed as a potential early indicator of sepsis onset. However, the exact role of non-neuronal AChE activity in sepsis and its correlation with disease severity and patient outcomes remain unclear. This study aimed to investigate the involvement of AChE activity in sepsis and evaluate its association with disease severity and clinical outcomes. (2) Methods: A prospective study included 43 septic patients. AChE activity was measured at sepsis detection, as well as 7 and 28 days later. Inflammatory biomarkers, disease severity scores, and patient outcomes were evaluated. (3) Results: AChE activity remained stable for 7 days and decreased at 28 days. However, there was no correlation between initial AChE activity and inflammatory biomarkers, disease severity scores, ICU stay, or hospital stay. (4) Conclusions: Non-neuronal AChE activity may not reliably indicate early sepsis or predict disease severity.
(1) 背景：脓毒症是一种严重的全身性炎症状态，其特征为临床迅速恶化和器官功能障碍。胆碱能系统参与调节炎症反应。乙酰胆碱酯酶（AChE）是一种主要负责水解乙酰胆碱的酶，已被认为是脓毒症发作的潜在早期指标。然而，非神经元AChE活性在脓毒症中的确切作用及其与疾病严重程度和患者预后的相关性仍不清楚。本研究旨在探讨AChE活性在脓毒症中的作用，并评估其与疾病严重程度和临床结局的关联。(2) 方法：一项前瞻性研究纳入了43例脓毒症患者。在脓毒症检测时以及之后的第7天和第28天测量AChE活性。评估炎症生物标志物、疾病严重程度评分和患者结局。(3) 结果：AChE活性在7天内保持稳定，并在第28天下降。然而，初始AChE活性与炎症生物标志物、疾病严重程度评分、入住重症监护病房时间或住院时间之间没有相关性。(4) 结论：非神经元AChE活性可能无法可靠地指示早期脓毒症或预测疾病严重程度。
