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酸枣矿泉水疗法对特应性皮炎小鼠模型的治疗作用及免疫调节作用

Therapeutic effects and immunomodulation of suanbo mineral water therapy in a murine model of atopic dermatitis.

作者信息

Choi Yoon Jung, Lee Hye Jin, Lee Do Hyun, Woo So Youn, Lee Kyung Ho, Yun Seong Taek, Kim Jong Moon, Kim Hong Jig, Kim Jin Wou

机构信息

Department of Dermatology, The Catholic University of Korea Uijeongbu St. Mary's Hospital, Uijeongbu, Korea.

Department of Microbiology, Ewha Womans University School of Medicine, Seoul, Korea.

出版信息

Ann Dermatol. 2013 Nov;25(4):462-70. doi: 10.5021/ad.2013.25.4.462. Epub 2013 Nov 30.

DOI:10.5021/ad.2013.25.4.462
PMID:24371394
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3870215/
Abstract

BACKGROUND

Balneotherapy is widely used as an alternative treatment modality for AD. Although the clinical benefit of some mineral waters has been established, their mechanisms of action in alleviating AD are only partly understood.

OBJECTIVE

The clinical modification and immunomodulatory or anti-inflammatory effects of mineral water from the Suanbo hot springs on the differentiation and cytokine production of Th1, Th2, and regulatory T cells (Treg) were investigated using spleen, skin tissue, and serum from NC/Nga mice.

METHODS

The therapeutic effects of bathing in mineral water in a Dermatophagoides farinae body extract ointment (Dfb ointment)-induced AD mouse model were assessed by measuring the modified Scoring atopic dermatitis (SCORAD) index scores, transepidermal water loss (TEWL), histological and immunohistochemical changes of the skin lesion, serum levels of interferon (IFN)-γ, interleukin (IL)-4, IL-5 and immunoglobulin E, mRNA expression of IFN-γ, IL-4 and IL-5 of dorsal skin, and helper T cell differentiation in the spleen.

RESULTS

Bathing in mineral water significantly reduced the modified SCORAD index scores, TEWL, epidermal hyperplasia, and inflammatory cell infiltration. IL-4 production and Th2 cell differentiation showed a decreasing tendency with mineral water bathing, but the Th1 cells did not. On the contrary, differentiation to Treg cells was promoted with mineral water bathing.

CONCLUSION

Balneotherapy not only has anti-inflammatory activity, but also shows positive effects on cutaneous barrier homeostasis. These results suggest that the favorable effects of balneotherapy may be mediated by modifying the Th2 response, and possibly in part by inducing Treg cell differentiation.

摘要

背景

浴疗法被广泛用作治疗特应性皮炎（AD）的替代治疗方式。尽管某些矿泉水的临床益处已得到证实，但其缓解AD的作用机制仅得到部分了解。

目的

使用NC/Nga小鼠的脾脏、皮肤组织和血清，研究酸泊温泉矿泉水对Th1、Th2和调节性T细胞（Treg）分化及细胞因子产生的临床改善作用以及免疫调节或抗炎作用。

方法

通过测量改良特应性皮炎评分（SCORAD）指数、经表皮水分流失（TEWL）、皮肤病变的组织学和免疫组化变化、血清中干扰素（IFN）-γ、白细胞介素（IL）-4、IL-5和免疫球蛋白E的水平、背部皮肤中IFN-γ、IL-4和IL-5的mRNA表达以及脾脏中辅助性T细胞的分化，评估在粉尘螨提取物软膏（Dfb软膏）诱导的AD小鼠模型中泡矿泉水的治疗效果。

结果

泡矿泉水可显著降低改良SCORAD指数、TEWL、表皮增生和炎性细胞浸润。泡矿泉水使IL-4产生和Th2细胞分化呈下降趋势，但Th1细胞未出现此现象。相反，泡矿泉水可促进向Treg细胞的分化。

结论

浴疗法不仅具有抗炎活性，还对皮肤屏障稳态具有积极作用。这些结果表明，浴疗法的有益效果可能通过改变Th2反应介导，并且可能部分通过诱导Treg细胞分化实现。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ca1/3870215/5c32cd9422aa/ad-25-462-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ca1/3870215/64b7cfd895cd/ad-25-462-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ca1/3870215/3b51a45bbb88/ad-25-462-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ca1/3870215/09f8013c0270/ad-25-462-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ca1/3870215/054f6784abc4/ad-25-462-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ca1/3870215/2c1d1ea7835e/ad-25-462-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ca1/3870215/8314e6e3ccfe/ad-25-462-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ca1/3870215/5c32cd9422aa/ad-25-462-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ca1/3870215/64b7cfd895cd/ad-25-462-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ca1/3870215/3b51a45bbb88/ad-25-462-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ca1/3870215/09f8013c0270/ad-25-462-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ca1/3870215/054f6784abc4/ad-25-462-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ca1/3870215/2c1d1ea7835e/ad-25-462-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ca1/3870215/8314e6e3ccfe/ad-25-462-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ca1/3870215/5c32cd9422aa/ad-25-462-g007.jpg

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