燕麦β-葡聚糖可改善高脂高果糖饮食喂养的小鼠的胰岛素抵抗。

Oat beta-glucan ameliorates insulin resistance in mice fed on high-fat and high-fructose diet.

机构信息

College of Food Science, Southwest University, Chongqing, China ; Department of Chemistry and Chemical Engineering, Chongqing University, Chongqing, China.

Department of Chemistry and Chemical Engineering, Chongqing University, Chongqing, China.

出版信息

Food Nutr Res. 2013 Dec 20;57. doi: 10.3402/fnr.v57i0.22754. eCollection 2013.

METHODS

This study sought to evaluate the impact of oat beta-glucan on insulin resistance in mice fed on high-fat and high-fructose diet with fructose (10%, w/v) added in drinking water for 10 weeks.

RESULTS

The results showed that supplementation with oat beta-glucan could significantly reduce the insulin resistance both in low-dose (200 mg/kg(-1) body weight) and high-dose (500 mg/kg(-1) body weight) groups, but the high-dose group showed a more significant improvement in insulin resistance (P<0.01) compared with model control (MC) group along with significant improvement in hepatic glycogen level, oral glucose, and insulin tolerance. Moreover, hepatic glucokinase activity was markedly enhanced both in low-dose and high-dose groups compared with that of MC group (P<0.05).

CONCLUSION

These results suggested that supplementation of oat beta-glucan alleviated insulin resistance and the effect was dose dependent.

方法

本研究旨在评估燕麦β-葡聚糖对给予高脂肪高果糖饮食（在饮水中添加 10%果糖，w/v）并持续 10 周的小鼠胰岛素抵抗的影响。

结果

结果表明，燕麦β-葡聚糖的补充可显著降低低剂量（200mg/kg(-1)体重）和高剂量（500mg/kg(-1)体重）组的胰岛素抵抗，但与模型对照组（MC 组）相比，高剂量组的胰岛素抵抗改善更为显著（P<0.01），同时肝糖原水平、口服葡萄糖耐量和胰岛素耐量也显著改善。此外，与 MC 组相比，低剂量和高剂量组的肝葡萄糖激酶活性均明显增强（P<0.05）。