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Commentary: Beyond "TRIM" Benefits of β-Glucan by Blood Glucose and Lipid Balancing Potentials in Its Defense Against COVID-19.述评：β-葡聚糖在抵御COVID-19中的作用超越“TRIM”——基于其调节血糖和血脂的益处
Front Immunol. 2021 Mar 29;12:620658. doi: 10.3389/fimmu.2021.620658. eCollection 2021.
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β-glucans: wide-spectrum immune-balancing food-supplement-based enteric (β-WIFE) vaccine adjuvant approach to COVID-19.β-葡聚糖：广谱免疫平衡的基于食物补充剂的肠内（β-WIFE）疫苗佐剂方法用于 COVID-19。
Hum Vaccin Immunother. 2021 Aug 3;17(8):2808-2813. doi: 10.1080/21645515.2021.1880210. Epub 2021 Mar 2.
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Potentials to alleviate coagulopathy and enhance microglial function of beta (β)- glucans, making them worth a clinical study for COVID-19's neurological sequalae.β-葡聚糖具有缓解凝血病和增强小胶质细胞功能的潜力，使其值得针对新冠病毒肺炎的神经后遗症开展临床研究。
J Neurol Sci. 2021 Aug 15;427:117554. doi: 10.1016/j.jns.2021.117554. Epub 2021 Jun 22.
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A randomized Placebo-Controlled Clinical Trial to Evaluate the Medium-Term Effects of Oat Fibers on Human Health: The Beta-Glucan Effects on Lipid Profile, Glycemia and inTestinal Health (BELT) Study.一项评价燕麦纤维对人体健康的中期影响的随机安慰剂对照临床试验：β-葡聚糖对血脂、血糖和肠道健康的影响（BELT 研究）。
Nutrients. 2020 Mar 3;12(3):686. doi: 10.3390/nu12030686.
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Ingestion of beta-glucans could stimulate longer-lasting cellular immunity upon administration of COVID-19 vaccines.摄入β-葡聚糖可能会在接种新冠疫苗后刺激产生更持久的细胞免疫。
J Food Biochem. 2021 Nov;45(11):e13959. doi: 10.1111/jfbc.13959. Epub 2021 Oct 5.
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[Effects of beta glucan in highland barley on blood glucose and serum lipid in high fat-induced C57 mouse].[青稞β-葡聚糖对高脂诱导C57小鼠血糖及血脂的影响]
Zhonghua Yu Fang Yi Xue Za Zhi. 2013 Jan;47(1):55-8.
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Lipid content of microparticulate (1-->3)-beta-D-glucan isolated from Saccharomyces cerevisiae.从酿酒酵母中分离出的微粒状（1→3）-β-D-葡聚糖的脂质含量。
Microbios. 1994;79(321):253-61.
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Elevated fasting blood glucose at admission is associated with poor outcomes in patients with COVID-19.入院时空腹血糖升高与2019冠状病毒病患者的不良预后相关。
Diabetes Metab. 2021 Mar;47(2):101189. doi: 10.1016/j.diabet.2020.08.004. Epub 2020 Sep 4.
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Post-prandial responses to cereal products enriched with barley beta-glucan.对富含大麦β-葡聚糖的谷物产品的餐后反应。
J Am Coll Nutr. 2006 Aug;25(4):313-20. doi: 10.1080/07315724.2006.10719541.
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Oat-derived beta-glucan significantly improves HDLC and diminishes LDLC and non-HDL cholesterol in overweight individuals with mild hypercholesterolemia.燕麦来源的β-葡聚糖可显著提高轻度高胆固醇血症超重个体的高密度脂蛋白胆固醇（HDLC）水平，并降低低密度脂蛋白胆固醇（LDLC）和非高密度脂蛋白胆固醇水平。
Am J Ther. 2007 Mar-Apr;14(2):203-12. doi: 10.1097/01.pap.0000249917.96509.e7.
引用本文的文献
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Clinical benefits of β-glucan supplementation in children: a review.补充β-葡聚糖对儿童的临床益处：综述
Discov Food. 2022;2(1):37. doi: 10.1007/s44187-022-00038-0. Epub 2022 Dec 27.
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Beta 1,3-1,6 Glucans Produced by Two Novel Strains of Aureobasidium Pullulans Exert Immune and Metabolic Beneficial Effects in Healthy Middle-aged Japanese Men: Results of an Exploratory Randomized Control Study.两种新型出芽短梗霉产生的β-1,3-1,6葡聚糖对健康中年日本男性的免疫和代谢具有有益作用：一项探索性随机对照研究的结果
JAR Life. 2023 Jul 28;12:61-71. doi: 10.14283/jarlife.2023.11. eCollection 2023.
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Natural Polymeric Composites Derived from Animals, Plants, and Microbes for Vaccine Delivery and Adjuvant Applications: A Review.源自动物、植物和微生物的天然高分子复合材料在疫苗递送和佐剂应用中的研究进展综述
Gels. 2023 Mar 15;9(3):227. doi: 10.3390/gels9030227.
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Hepatoprotective Effects of Derived β 1,3-1,6 Glucans in a Murine Model of Non-alcoholic Steatohepatitis.非酒精性脂肪性肝炎小鼠模型中衍生的β-1,3-1,6-葡聚糖的肝保护作用
J Clin Exp Hepatol. 2022 Nov-Dec;12(6):1428-1437. doi: 10.1016/j.jceh.2022.06.008. Epub 2022 Jun 27.
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Beneficial effects of novel aureobasidium pullulans strains produced beta-1,3-1,6 glucans on interleukin-6 and D-dimer levels in COVID-19 patients; results of a randomized multiple-arm pilot clinical study.新型出芽短梗霉菌株产生的β-1,3-1,6 葡聚糖对 COVID-19 患者白细胞介素-6 和 D-二聚体水平的有益影响;一项随机多臂先导临床研究的结果。
Biomed Pharmacother. 2022 Jan;145:112243. doi: 10.1016/j.biopha.2021.112243. Epub 2021 Sep 25.
本文引用的文献
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Biological response modifier glucan through balancing of blood glucose may have a prophylactic potential in COVID-19 patients.生物反应调节剂葡聚糖通过平衡血糖可能对新冠肺炎患者具有预防潜力。
J Diabetes Metab Disord. 2020 Oct 21;19(2):2041-2044. doi: 10.1007/s40200-020-00664-4. eCollection 2020 Dec.
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Coagulopathy associated with COVID-19 - Perspectives & Preventive strategies using a biological response modifier Glucan.与新型冠状病毒肺炎相关的凝血病——使用生物反应调节剂葡聚糖的观点及预防策略
Thromb J. 2020 Oct 16;18:27. doi: 10.1186/s12959-020-00239-6. eCollection 2020.
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Dyslipidemia is associated with severe coronavirus disease 2019 (COVID-19) infection.血脂异常与2019冠状病毒病（COVID-19）重症感染相关。
Diabetes Metab Syndr. 2020 Sep-Oct;14(5):1463-1465. doi: 10.1016/j.dsx.2020.07.054. Epub 2020 Aug 1.
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Could the Induction of Trained Immunity by β-Glucan Serve as a Defense Against COVID-19?β-葡聚糖诱导的训练免疫能否成为预防 COVID-19 的手段？
Front Immunol. 2020 Jul 14;11:1782. doi: 10.3389/fimmu.2020.01782. eCollection 2020.
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Role of Immune Dysregulation in Increased Mortality Among a Specific Subset of COVID-19 Patients and Immune-Enhancement Strategies for Combatting Through Nutritional Supplements.免疫失调在特定 COVID-19 患者群体死亡率升高中的作用，以及通过营养补充剂增强免疫力的策略。
Front Immunol. 2020 Jul 9;11:1548. doi: 10.3389/fimmu.2020.01548. eCollection 2020.
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Fasting blood glucose at admission is an independent predictor for 28-day mortality in patients with COVID-19 without previous diagnosis of diabetes: a multi-centre retrospective study.入院时的空腹血糖是 COVID-19 患者（无既往糖尿病诊断）28 天死亡率的独立预测因子：一项多中心回顾性研究。
Diabetologia. 2020 Oct;63(10):2102-2111. doi: 10.1007/s00125-020-05209-1. Epub 2020 Jul 10.
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Admission fasting blood glucose predicts 30-day poor outcome in patients hospitalized for COVID-19 pneumonia.入院时的空腹血糖可预测因新冠肺炎肺炎住院患者的30天不良结局。
Diabetes Obes Metab. 2020 Oct;22(10):1955-1957. doi: 10.1111/dom.14132. Epub 2020 Aug 4.
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Mechanism of inflammatory response in associated comorbidities in COVID-19.2019冠状病毒病相关合并症中炎症反应的机制
Diabetes Metab Syndr. 2020 Jul-Aug;14(4):597-600. doi: 10.1016/j.dsx.2020.05.025. Epub 2020 May 12.
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COVID-19 and diabetes: Knowledge in progress.新型冠状病毒肺炎与糖尿病：知识在不断更新。
Diabetes Res Clin Pract. 2020 Apr;162:108142. doi: 10.1016/j.diabres.2020.108142. Epub 2020 Apr 9.
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Insulin Signaling and Insulin Resistance Facilitate Trained Immunity in Macrophages Through Metabolic and Epigenetic Changes.胰岛素信号和胰岛素抵抗通过代谢和表观遗传变化促进巨噬细胞的训练免疫。
Front Immunol. 2019 Jun 12;10:1330. doi: 10.3389/fimmu.2019.01330. eCollection 2019.
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