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一名患有考登综合征的年轻女性同时存在非典型息肉样腺肌瘤和子宫内膜样子宫内膜癌：病例报告及对筛查和预防的启示

Coexisting atypical polypoid adenomyoma and endometrioid endometrial carcinoma in a young woman with Cowden Syndrome: Case report and implications for screening and prevention.

作者信息

Edwards James M, Alsop Skylar, Modesitt Susan C

机构信息

Department of Obstetrics and Gynecology, Duke University Medical Center, DUMC Box 3616, Durham, NC, USA.

Department of Pathology, Maryview Medical Center, 3636 High Street, Portsmouth, VA 23707, USA.

出版信息

Gynecol Oncol Case Rep. 2012 Jan 5;2(2):29-31. doi: 10.1016/j.gynor.2011.12.004. eCollection 2012.

DOI:10.1016/j.gynor.2011.12.004
PMID:24371612
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3861268/
Abstract

► Cowden Syndrome is a rare hereditary cancer syndrome, which confers an increased risk of breast, thyroid, endometrial and colon cancer. ► Atypical polypoid adenomyoma does not generally represent a premalignant lesion, but must be carefully screened for foci of malignancy. ► Cancer screening must be intensified for patients who meet the diagnostic criteria for Cowden Syndrome.

摘要

► 考登综合征是一种罕见的遗传性癌症综合征，会增加患乳腺癌、甲状腺癌、子宫内膜癌和结肠癌的风险。

► 非典型息肉样腺肌瘤一般不代表癌前病变，但必须仔细筛查恶性病灶。

► 对于符合考登综合征诊断标准的患者，必须加强癌症筛查。

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引用本文的文献

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Hereditary Syndromes Manifesting as Endometrial Carcinoma: How Can Pathological Features Aid Risk Assessment?表现为子宫内膜癌的遗传性综合征：病理特征如何有助于风险评估？
Biomed Res Int. 2015;2015:219012. doi: 10.1155/2015/219012. Epub 2015 Jun 16.

本文引用的文献

1
Molecular pathology of atypical polypoid adenomyoma of the uterus.子宫非典型息肉样腺肌瘤的分子病理学
Hum Pathol. 2003 Aug;34(8):784-8. doi: 10.1016/s0046-8177(03)00246-6.
2
Will the real Cowden syndrome please stand up: revised diagnostic criteria.真正的考登综合征请站出来：修订后的诊断标准。
J Med Genet. 2000 Nov;37(11):828-30. doi: 10.1136/jmg.37.11.828.
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PTEN mutations in endometrial carcinomas: a molecular and clinicopathologic analysis of 38 cases.
Hum Pathol. 2000 Mar;31(3):312-7. doi: 10.1016/s0046-8177(00)80244-0.
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Two cases of endometrial adenocarcinoma arising from atypical polypoid adenomyoma.两例起源于非典型息肉样腺肌瘤的子宫内膜腺癌。
Gynecol Oncol. 1998 Oct;71(1):141-4. doi: 10.1006/gyno.1998.5137.
5
Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN.肿瘤抑制因子PTEN对依赖蛋白激酶B/蛋白激酶B（PKB/Akt）的细胞存活的负调控。
Cell. 1998 Oct 2;95(1):29-39. doi: 10.1016/s0092-8674(00)81780-8.
6
Beta-catenin as oncogene: the smoking gun.β-连环蛋白作为癌基因：确凿证据。
Science. 1997 Mar 21;275(5307):1752-3. doi: 10.1126/science.275.5307.1752.
7
Localization of the gene for Cowden disease to chromosome 10q22-23.考登病基因定位于10号染色体q22 - 23区域。
Nat Genet. 1996 May;13(1):114-6. doi: 10.1038/ng0596-114.
8
Atypical polypoid adenomyofibromas (atypical polypoid adenomyomas) of the uterus. A clinicopathologic study of 55 cases.子宫非典型息肉样腺肌纤维瘤（非典型息肉样腺肌瘤）。55例临床病理研究。
Am J Surg Pathol. 1996 Jan;20(1):1-20. doi: 10.1097/00000478-199601000-00001.
9
Atypical polypoid adenomyomas of the endometrium.
Am J Surg Pathol. 1981 Jul;5(5):473-82. doi: 10.1097/00000478-198107000-00006.