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Gynecol Oncol Case Rep. 2012 Oct 8;3:1-3. doi: 10.1016/j.gynor.2012.09.004. eCollection 2012.
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A novel MXI1-NUTM2B fusion detected in an undifferentiated ovarian cancer.在一例未分化卵巢癌中检测到一种新型的MXI1-NUTM2B融合基因。
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本文引用的文献

1
Clinicopathologic features and long-term outcomes of NUT midline carcinoma.NUT 中线癌的临床病理特征和长期预后。
Clin Cancer Res. 2012 Oct 15;18(20):5773-9. doi: 10.1158/1078-0432.CCR-12-1153. Epub 2012 Aug 15.
2
Pathogenesis of NUT midline carcinoma.NUT 中线癌的发病机制。
Annu Rev Pathol. 2012;7:247-65. doi: 10.1146/annurev-pathol-011811-132438. Epub 2011 Oct 17.
3
Differentiation of NUT midline carcinoma by epigenomic reprogramming.通过表观基因组重编程来区分中央型 NUT 中线癌。
Cancer Res. 2011 Apr 1;71(7):2686-96. doi: 10.1158/0008-5472.CAN-10-3513. Epub 2011 Mar 29.
4
Diagnosis of NUT midline carcinoma using a NUT-specific monoclonal antibody.使用 NUT 特异性单克隆抗体诊断 NUT 中线癌。
Am J Surg Pathol. 2009 Jul;33(7):984-91. doi: 10.1097/PAS.0b013e318198d666.
5
BRD-NUT oncoproteins: a family of closely related nuclear proteins that block epithelial differentiation and maintain the growth of carcinoma cells.BRD-NUT癌蛋白：一类密切相关的核蛋白，可阻断上皮分化并维持癌细胞生长。
Oncogene. 2008 Apr 3;27(15):2237-42. doi: 10.1038/sj.onc.1210852. Epub 2007 Oct 15.
6
Midline carcinoma of children and young adults with NUT rearrangement.伴有NUT重排的儿童和青年中线癌
J Clin Oncol. 2004 Oct 15;22(20):4135-9. doi: 10.1200/JCO.2004.02.107.
7
BRD4-NUT fusion oncogene: a novel mechanism in aggressive carcinoma.BRD4-NUT融合致癌基因：侵袭性癌中的一种新机制。
Cancer Res. 2003 Jan 15;63(2):304-7.

一例罕见的NUT中线癌。

A rare case of NUT midline carcinoma.

作者信息

Ball Allison, Bromley Amy, Glaze Sarah, French Christopher A, Ghatage Prafull, Köbel Martin

机构信息

Division of Gynecologic Oncology, Tom Baker Cancer Centre, Calgary, AB, Canada.

Department of Pathology and Laboratory Medicine, University of Calgary, Calgary, AB, Canada.

出版信息

Gynecol Oncol Case Rep. 2012 Oct 8;3:1-3. doi: 10.1016/j.gynor.2012.09.004. eCollection 2012.

DOI:10.1016/j.gynor.2012.09.004
PMID:24371650
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3862205/
Abstract

► NUT midline carcinoma is a rare and aggressive cancer arising in midline structures and is of squamous cell lineage. ► Diagnosis by use of molecular tests is possible with clinical suspicion. ► NUT midline carcinoma is refractory to conventional treatments, but understanding of molecular alterations may lead to an effective therapy.

摘要

► NUT中线癌是一种罕见的侵袭性癌症，起源于中线结构，属于鳞状细胞谱系。

► 临床怀疑时可通过分子检测进行诊断。

► NUT中线癌对传统治疗无效，但了解分子改变可能会带来有效的治疗方法。