Sitzman Clarence
Peak Veterinary Specialists, Windsor, CO 80528, USA.
J Vet Dent. 2013 Fall;30(3):150-5. doi: 10.1177/089875641303000303.
A liquid solution, gingival sealant containing polymers that form a barrier film upon application was evaluated in dogs. It is a non-toxic, low viscosity, hydrophilic barrier sealant that dries in approximately 10 to 15-seconds after subgingival application. It was designed as a preventative to be applied immediately following a professional oral hygiene procedure in order to block plaque and calculus formation in the sulcus and aid in the prevention of periodontal disease in companion animals. Additionally, the polymer was designed to promote an aerobic environment in the sulcus by oxygen and water transport through engineered pores within the polymer. A 30-day split-mouth, blinded study in two groups of 15 beagle dogs was used. Plaque was significantly (p < 0.05) reduced on the side receiving the sealant by 30.0% and 50.5% (average = 40.3%) in groups 1 and 2, respectively. Calculus was significantly (p < 0.05) reduced on the side receiving the sealant by 27.2% and 20.0% (average = 23.6%) in groups 1 and 2, respectively. Gingival inflammation was monitored to assess product safety. Sides receiving sealant showed no statistically significant differences in gingival index score. No adverse events were observed in the study. This study demonstrates that this gingival sealant can be used as another valuable tool for aiding in the prevention of periodontal disease in dogs.
一种含有聚合物的液体牙龈封闭剂在犬类中进行了评估，该聚合物在应用后会形成一层阻隔膜。它是一种无毒、低粘度、亲水性的阻隔封闭剂，在龈下应用后大约10到15秒内干燥。它被设计为一种预防性产品，在专业口腔卫生程序后立即应用，以阻止龈沟内牙菌斑和牙结石的形成，并有助于预防伴侣动物的牙周疾病。此外，该聚合物旨在通过聚合物内设计的孔隙进行氧气和水的传输，从而在龈沟中促进需氧环境。在两组各15只比格犬中进行了一项为期30天的双盲、分口研究。在接受封闭剂的一侧，第1组和第2组的牙菌斑分别显著减少（p < 0.05）30.0%和50.5%（平均 = 40.3%）。在接受封闭剂的一侧，第1组和第2组的牙结石分别显著减少（p < 0.05）27.2%和20.0%（平均 = 23.6%）。监测牙龈炎症以评估产品安全性。接受封闭剂的一侧在牙龈指数评分上没有统计学上的显著差异。在该研究中未观察到不良事件。这项研究表明，这种牙龈封闭剂可作为预防犬类牙周疾病的另一种有价值的工具。
