Departments of Paediatric Dermatology & Children's Allergies, St John's Institute of Dermatology, Guy's and St Thomas' Hospitals NHS Foundation Trust and King's College, London, UK.
Allergy. 2014 Jan;69(1):56-61. doi: 10.1111/all.12343. Epub 2013 Dec 26.
There has been a steep rise in the burden of atopic dermatitis (AD), and up to 20% of children in developed countries now suffer of the disease. At present, treatment at best achieves symptom control rather than cure, and there is a strong need to identify new methods of disease prevention. While earlier approaches focused on allergen avoidance strategies, there has been a clear shift towards attempts to induce tolerance and enhancement of skin barrier function, as skin barrier breakdown plays an important role in AD development. This article reviews the latest developments in the prevention of AD.
特应性皮炎（AD）的负担急剧增加，现在发达国家多达 20%的儿童患有该病。目前，治疗最多只能实现症状控制而不是治愈，因此强烈需要确定新的疾病预防方法。虽然早期方法侧重于避免过敏原策略，但现在已经明显转向尝试诱导耐受和增强皮肤屏障功能，因为皮肤屏障破坏在 AD 发展中起着重要作用。本文综述了 AD 预防的最新进展。
