Vascular Biology & Stroke Research Laboratory, Department of Neurosurgery, Louisiana State University Health Sciences Center, 1501 Kings Highway, Shreveport, LA 71130, USA.
Curr Med Chem. 2014;21(19):2138-45. doi: 10.2174/0929867321666131227163352.
CD147, a transmembrane glycoprotein, is expressed on all leukocytes, platelets, and endothelial cells. It has been implicated in a variety of physiological and pathological activities through interacting with multiple partners, including cyclophilins, monocarboxylate transporters, Caveolin-1, and integrins. While CD147 is best known as a potent inducer of extracellular matrix metalloproteinases (hence also called EMMPRIN), it can also function as a key mediator of inflammatory and immune responses. Increased expression of CD147 has been implicated in the pathogenesis of a number of diseases, such as asthma-mediated lung inflammation, rheumatoid arthritis, multiple sclerosis, myocardial infarction and ischemic stroke. Therapeutic targeting of CD147 has yielded encouraging effects in a number of experimental models of human diseases, suggesting CD147 as an attractive target for treatment of inflammation-related diseases. Here we review the current understanding of CD147 expression and functions in inflammatory and immune responses and potential implications for treatment of inflammatory disorders.
CD147 是一种跨膜糖蛋白，存在于所有白细胞、血小板和内皮细胞上。它通过与多种配体相互作用，包括亲环素、单羧酸转运蛋白、Caveolin-1 和整合素，参与多种生理和病理活动。CD147 作为细胞外基质金属蛋白酶（因此也称为 EMMPRIN）的有效诱导物而广为人知，但它也可以作为炎症和免疫反应的关键介质。CD147 的表达增加与多种疾病的发病机制有关，如哮喘介导的肺炎症、类风湿性关节炎、多发性硬化症、心肌梗死和缺血性中风。在许多人类疾病的实验模型中，针对 CD147 的治疗靶向已经产生了令人鼓舞的效果，这表明 CD147 是治疗炎症相关疾病的一个有吸引力的靶点。在这里，我们综述了 CD147 在炎症和免疫反应中的表达和功能的最新认识，以及其对炎症性疾病治疗的潜在影响。
