Qin Qin, Wang Hui, Wang Huai-Zhou, Huang Yuan-Lan, Li Hu, Zhang Wei-Wei, Zhang Jian-Rong, He Ling-Ling, Xia Rong, Zhao Dong-Bao, Deng An-Mei
Department of Transfusion, Huashan Hospital, Fudan University , Shanghai , P. R. China.
Mod Rheumatol. 2014 Sep;24(5):793-7. doi: 10.3109/14397595.2013.865823. Epub 2013 Dec 29.
To estimate the diagnostic accuracy of anti-alpha-fodrin antibodies for primary Sjögren's syndrome (pSS).
Sixty-four pSS subjects and 108 non-pSS patients were prospectively enrolled in this study. Serum anti-alpha-fodrin IgA and IgG were detected by ELISA in a blind fashion. The diagnostic accuracy of anti-alpha-fodrin antibodies was assessed by receiver operating characteristic (ROC) curve analysis. Logistic regression was used to investigate whether anti-alpha-fodrin antibodies could improve the accuracy of pSS diagnosis if used in addition to anti-SSA and anti-SSB.
The areas under the ROC curves for anti-alpha-fodrin IgG and IgA were 0.69 (95% confidence interval (CI): 0.60-0.77) and 0.63 (95% CI: 0.54-0.72), respectively (P < 0.01 for both). The optimal diagnostic thresholds for anti-fodrin IgG and IgA were 11.75 U/ml and 9.75 U/ml, respectively, with a sensitivity of 0.59 and 0.55, and a specificity of 0.75 and 0.73, respectively. Anti-alpha-fodrin IgG and IgA antibodies were associated with pSS after adjustment for anti-SSA and anti-SSB.
Anti-alpha-fodrin IgG and IgA antibodies are useful diagnostic markers which may improve the accuracy of pSS diagnosis.
评估抗α - fodrin抗体对原发性干燥综合征（pSS）的诊断准确性。
本研究前瞻性纳入了64例pSS患者和108例非pSS患者。采用酶联免疫吸附测定（ELISA）法以盲法检测血清抗α - fodrin IgA和IgG。通过受试者工作特征（ROC）曲线分析评估抗α - fodrin抗体的诊断准确性。使用逻辑回归研究抗α - fodrin抗体若与抗SSA和抗SSB联合使用是否能提高pSS诊断的准确性。
抗α - fodrin IgG和IgA的ROC曲线下面积分别为0.69（95%置信区间（CI）：0.60 - 0.77）和0.63（95% CI：0.54 - 0.72）（两者P均<0.01）。抗fodrin IgG和IgA的最佳诊断阈值分别为11.75 U/ml和9.75 U/ml，敏感性分别为0.59和0.55，特异性分别为0.75和0.73。校正抗SSA和抗SSB后，抗α - fodrin IgG和IgA抗体与pSS相关。
抗α - fodrin IgG和IgA抗体是有用的诊断标志物，可能提高pSS诊断的准确性。
Zotero 插件