碘(III)介导的 1,3-二羰基化合物的卤化和叠氮化的统一策略。
Unified strategy for iodine(III)-mediated halogenation and azidation of 1,3-dicarbonyl compounds.
机构信息
Centre for Synthesis and Chemical Biology, School of Chemistry and Chemical Biology, University College Dublin , Belfield, Dublin 4, Ireland.
出版信息
Org Lett. 2014 Jan 17;16(2):600-3. doi: 10.1021/ol403504z. Epub 2013 Dec 27.
PMID:24372311
Abstract
A mild and rapid (diacetoxyiodo)benzene-mediated formal electrophilic α-azidation of 1,3-dicarbonyl compounds using commercially available Bu4NN3 as the azide source is reported. The reaction conditions employed are based on optimization studies conducted on the analogous halogenations with Et4NX (X = Cl, Br, I).
摘要
本文报道了一种温和、快速的（二乙酰氧基碘代）苯介导的 1,3-二羰基化合物的亲电α-叠氮化反应，使用商业可得的 Bu4NN3 作为叠氮源。反应条件是基于对类似的卤化反应（Et4NX，X = Cl、Br、I）进行优化研究得到的。
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