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橄榄苦苷及其含氧衍生物的合成与活性研究。

Synthesis and Activity against of Olivacine and Oxygenated Derivatives.

机构信息

Faculty of Chemistry, Technische Universität Dresden, Bergstraße 66, 01069 Dresden, Germany.

A. M. Butlerov Chemistry Institute, Kazan Federal University, Kremlevskaya Str. 18, Kazan 420008, Russia.

出版信息

Molecules. 2018 Jun 9;23(6):1402. doi: 10.3390/molecules23061402.

DOI:10.3390/molecules23061402
PMID:29890747
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6100493/
Abstract

The tetracyclic pyrido[4,3-]carbazole olivacine and four of its oxygenated derivatives have been synthesized by a late-stage palladium-catalyzed Heck-type cyclization of the pyrrole ring as a key step. In a test for the inhibition of the growth of , 9-methoxyolivacine showed the most significant inhibitory activity against with an MIC value of 1.5 μM.

摘要

四氢吡咯并[4,3-]咔唑类奥来菪因及其 4 个氧化衍生物通过关键的晚期钯催化 Heck 型吡咯环环化反应合成。在抑制生长的测试中，9-甲氧基奥来菪因对显示出最显著的抑制活性，MIC 值为 1.5 μM。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e8c/6100493/11740605adae/molecules-23-01402-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e8c/6100493/c05bbe628f63/molecules-23-01402-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e8c/6100493/481d4b425ce4/molecules-23-01402-sch001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e8c/6100493/41533029c7b2/molecules-23-01402-sch002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e8c/6100493/2d1b47ea2487/molecules-23-01402-sch003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e8c/6100493/eff3309885c1/molecules-23-01402-sch004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e8c/6100493/31649ca659db/molecules-23-01402-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e8c/6100493/4cf3454a99cb/molecules-23-01402-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e8c/6100493/11740605adae/molecules-23-01402-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e8c/6100493/c05bbe628f63/molecules-23-01402-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e8c/6100493/481d4b425ce4/molecules-23-01402-sch001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e8c/6100493/41533029c7b2/molecules-23-01402-sch002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e8c/6100493/2d1b47ea2487/molecules-23-01402-sch003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e8c/6100493/eff3309885c1/molecules-23-01402-sch004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e8c/6100493/31649ca659db/molecules-23-01402-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e8c/6100493/4cf3454a99cb/molecules-23-01402-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e8c/6100493/11740605adae/molecules-23-01402-g004.jpg

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