2型补体受体（CR2）的功能和抗原特性。
Functional and antigenic properties of complement receptor type 2, CR2.
作者信息
Mitomo K, Fujita T, Iida K
出版信息
J Exp Med. 1987 May 1;165(5):1424-9. doi: 10.1084/jem.165.5.1424.
Abstract
This is the first report demonstrating that C3d receptor (CR2) has functional activity in regulating complement cascade. Purified CR2 was examined for its cofactor activity in factor I-mediated cleavage of membrane-bound iC3b. CR2 plus C3b inactivator (I) released C3c from EA 125I-iC3b, and the release was inhibited when CR2 was preincubated with OKB7 monoclonal anti-CR2. Furthermore, immunoelectroblotting analysis showed crossreactivity of CR2 with 57H anti-CR1. These results indicate that CR2 has functional and antigenic similarity to CR1, thus providing a supporting evidence for placement of CR2 as a member of the recently defined gene family of C3- and C4-regulatory proteins composed of CR1, C4-binding protein, and factor H.
摘要
这是首份证明C3d受体（CR2）在调节补体级联反应中具有功能活性的报告。检测了纯化的CR2在I因子介导的膜结合iC3b裂解中的辅因子活性。CR2加C3b灭活剂（I）可从EA 125I-iC3b中释放出C3c，当CR2与OKB7单克隆抗CR2预孵育时，这种释放受到抑制。此外，免疫印迹分析显示CR2与57H抗CR1有交叉反应性。这些结果表明CR2与CR1在功能和抗原性上相似，从而为将CR2归为最近定义的由CR1、C4结合蛋白和H因子组成的C3和C4调节蛋白基因家族成员提供了支持证据。
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本文引用的文献
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Generation of three different fragments of bound C3 with purified factor I or serum. II. Location of binding sites in the C3 fragments for factors B and H, complement receptors, and bovine conglutinin.用纯化的I因子或血清生成结合C3的三种不同片段。II. C3片段中B因子、H因子、补体受体和牛胶固素结合位点的定位。
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Human lymphocytes bear membrane receptors for C3b and C3d.人类淋巴细胞带有C3b和C3d的膜受体。
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