Department of Gastroenterology and Hepatology, Osaka Red Cross Hospital, Osaka, Japan.
J Gastroenterol Hepatol. 2014 May;29(5):951-6. doi: 10.1111/jgh.12512.
The significance of gastric xanthelasma in relation to gastric disease still remains unclear. We investigated the prevalence and significance of gastric xanthelasma in patients with atrophic gastritis and gastric cancer.
A total of 3238 patients who underwent endoscopic examinations of the upper gastrointestinal tract were enrolled. We retrospectively investigated the presence of gastric xanthelasma, the severity of gastric atrophy, and the presence of gastric cancer, and examined the relationship between gastric xanthelasma and various clinicopathological features.
Gastric xanthelasma was detected in 249 (7.7%) of the 3238 patients and was significantly associated with age ≥ 65 years, male gender, open-type atrophy, and the presence of gastric cancer (P < 0.0001, P = 0.0002, P < 0.0001 and P < 0.0001, respectively). Multivariate analysis revealed that the presence of gastric cancer was independently related to the presence of gastric xanthelasma (odds ratio 6.19 [3.95-9.70], P < 0.0001). Age/sex/atrophy-matched control analysis demonstrated that the presence of gastric xanthelasma was significantly associated with the presence of gastric cancer (P < 0.0001). Moreover, the presence of xanthelasma in the upper region of the stomach was significantly associated with gastric cancer (P = 0.002). Gastric xanthelasma was observed in 50 (47.6%) of 105 patients with gastric cancer.
Gastric xanthelasma may serve as a warning sign for the presence of gastric cancer.
胃黄色瘤与胃部疾病的关系意义仍不明确。我们研究了萎缩性胃炎和胃癌患者胃黄色瘤的患病率和意义。
共纳入 3238 例行上消化道内镜检查的患者。我们回顾性调查了胃黄色瘤、胃萎缩严重程度和胃癌的存在情况，并检查了胃黄色瘤与各种临床病理特征之间的关系。
在 3238 例患者中，发现 249 例（7.7%）存在胃黄色瘤，其与年龄≥65 岁、男性、开放型萎缩和胃癌显著相关（P<0.0001、P=0.0002、P<0.0001 和 P<0.0001）。多变量分析显示，胃癌的存在与胃黄色瘤的存在独立相关（比值比 6.19[3.95-9.70]，P<0.0001）。年龄/性别/萎缩匹配对照分析显示，胃黄色瘤的存在与胃癌的存在显著相关（P<0.0001）。此外，胃上部存在黄色瘤与胃癌显著相关（P=0.002）。在 105 例胃癌患者中观察到胃黄色瘤 50 例（47.6%）。
胃黄色瘤可能是胃癌存在的警告信号。
