Sotiropoulos Christos, Theocharis Georgios J, Thomopoulos Konstantinos C
Gastroenterology, University General Hospital of Patras, Patras, GRC.
Cureus. 2024 Jul 24;16(7):e65296. doi: 10.7759/cureus.65296. eCollection 2024 Jul.
Gastrointestinal tract xanthomas are rarely encountered findings in upper gastrointestinal endoscopy. They are non-tumor, well-demarcated, yellowish mucosal plaques most commonly diagnosed in the stomach, especially in the antrum or the pyloric region. Histologically, a gastric xanthoma consists of foamy histiocytes in the lamina propria. Although it is a benign lesion, it can be associated with various precancerous conditions and its appearance can resemble malignancy. We report the case of a 74-year-old female patient who presented to the outpatient clinic with a six-month history of intermittent pain in the epigastrium. The patient's physical examination as well as the hematological and biochemical investigations were normal. The upper gastrointestinal endoscopy revealed yellowish plaques in the pyloric antrum of the stomach, which were diagnosed as gastric xanthomas by histological examination. The significance of gastric xanthomas in relation to gastric disease still remains to be determined. Given the frequent association of gastric xanthomas and known premalignant lesions and occasionally malignant changes of the gastric mucosa, we need to pay close attention to endoscopic diagnosis and histochemical and immunohistochemical evaluation.
胃肠道黄色瘤是上消化道内镜检查中罕见的发现。它们是非肿瘤性、边界清晰的黄色黏膜斑块，最常见于胃，尤其是胃窦或幽门区域。组织学上，胃黄色瘤由固有层中的泡沫状组织细胞组成。虽然它是一种良性病变，但可能与各种癌前病变相关，其外观可能类似恶性肿瘤。我们报告一例74岁女性患者，她因上腹部间歇性疼痛6个月就诊于门诊。患者的体格检查以及血液学和生化检查均正常。上消化道内镜检查发现胃幽门窦有黄色斑块，经组织学检查诊断为胃黄色瘤。胃黄色瘤与胃部疾病的关系仍有待确定。鉴于胃黄色瘤与已知的癌前病变以及胃黏膜偶尔的恶性变化频繁相关，我们需要密切关注内镜诊断以及组织化学和免疫组织化学评估。
