Sekikawa Akira, Fukui Hirokazu, Sada Ryota, Fukuhara Manabu, Marui Saiko, Tanke Gensho, Endo Masatsugu, Ohara Yoshiaki, Matsuda Fumihiro, Nakajima Jun, Henmi Shinichiro, Saito Sumio, Tsumura Takehiko, Maruo Takanori, Kimura Toru, Osaki Yukio
Department of Gastroenterology and Hepatology, Osaka Red Cross Hospital, 5-30, Fudegasaki, Tennoji-ku, Osaka, 543-8555, Japan.
Division of Gastroenterology, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan.
J Gastroenterol. 2016 Jan;51(1):35-42. doi: 10.1007/s00535-015-1081-0. Epub 2015 Apr 23.
The significance of gastric xanthelasma in relation to gastric cancer still remains unclear. We investigated whether gastric xanthelasma would be a useful marker for predicting the development of early gastric cancer.
A total of 1823 patients who underwent a medical health checkup were enrolled. We examined the relationship between gastric xanthelasma and various clinical features, and in an endoscopic follow-up study investigated whether the presence of gastric xanthelasma was predictive of the development of early gastric cancer.
In the initial endoscopic examination, gastric xanthelasma was detected in 107 (5.9 %) of the 1823 patients. The presence of gastric xanthelasma was significantly associated with age ≥65 years, male gender, open-type atrophy, and the presence of diabetes mellitus (DM) (p < 0.0001, p < 0.0001, p < 0.0001, and p < 0.0001, respectively). During the endoscopic follow-up period, early gastric cancer was found in 29 (1.6 %) of the 1823 patients. Gastric cancer occurred in 15 (14.0 %) of 107 patients with gastric xanthelasma, whereas it occurred in 14 (0.8 %) of 1716 patients without (p < 0.0001). Multivariate analysis revealed that open-type atrophy and gastric xanthelasma were independently related to the development of gastric cancer (odds ratio 7.19 [2.50-20.83]; p = 0.0003 and 5.85 [2.67-12.82]; p < 0.0001, respectively). The presence of gastric xanthelasma was significantly predictive of gastric cancer development even in the selected high-risk groups with open-type atrophy or DM (p < 0.0001 or p < 0.0001, respectively).
Gastric xanthelasma is a useful marker for predicting the development of gastric cancer.
胃黄斑瘤与胃癌的关系仍不明确。我们研究了胃黄斑瘤是否可作为预测早期胃癌发生的有用标志物。
共纳入1823例接受健康体检的患者。我们检查了胃黄斑瘤与各种临床特征之间的关系，并在一项内镜随访研究中调查胃黄斑瘤的存在是否可预测早期胃癌的发生。
在初次内镜检查中，1823例患者中有107例（5.9%）检测到胃黄斑瘤。胃黄斑瘤的存在与年龄≥65岁、男性、开放型萎缩以及糖尿病（DM）显著相关（p分别<0.0001、<0.0001、<0.0001和<0.0001）。在内镜随访期间，1823例患者中有29例（1.6%）发现早期胃癌。107例有胃黄斑瘤的患者中有15例（14.0%）发生胃癌，而1716例无胃黄斑瘤的患者中有14例（0.8%）发生胃癌（p<0.0001）。多因素分析显示，开放型萎缩和胃黄斑瘤与胃癌的发生独立相关（优势比分别为7.19[2.50 - 20.83]；p = 0.0003和5.85[2.67 - 12.82]；p<0.0001）。即使在选定的具有开放型萎缩或糖尿病的高危组中，胃黄斑瘤的存在也显著预测胃癌的发生（p分别<0.0001或<0.0001）。
胃黄斑瘤是预测胃癌发生的有用标志物。
