Department of Gastroenterology, Jiading Hospital of Traditional Chinese Medicine, Shanghai 201800, P.R. China.
Department of Oncology, Jiading Hospital of Traditional Chinese Medicine, Shanghai 201800, P.R. China.
Oncol Rep. 2020 Sep;44(3):1275-1281. doi: 10.3892/or.2020.7651. Epub 2020 Jun 19.
Certain conflicting conclusions have been drawn that gastric xanthelasma is related to H. pylori, atrophic gastritis, intestinal metaplasia, and early gastric cancer. The aim of this study was to examine the relationship between gastric xanthelasma and upper gastrointestinal (GI) endoscopic or pathological features. A cross‑sectional study was completed. A total of 8,634 patients who underwent stomach biopsy and who had no gastrectomy history were enrolled in the study. The patients were divided into two groups according to the presence or absence of gastric xanthelasma. The relationship between gastric xanthelasma and demographic characteristics (including age and sex), endoscopic features (including peptic ulcer, bile reflux, and gastric poly), or pathological features (including atrophy, intestinal metaplasia, H. pylori, dysplasia, and gastric cancer) was analyzed. Age/sex matched analysis was also performed to exclude the influence of age and sex. The results revealed that out of the 8,634 patients, 3.54% patients had xanthelasma. Gastric xanthelasma was significantly associated with age (55.76 vs. 49.17 years, P<0.0001), duodenal ulcer (OR 0.860, 95% CI 0.369‑0.923), atrophy (OR 1.839, 95% CI 1.432‑2.362), and intestinal metaplasia (OR 3.296, 95% CI 2.612‑4.159). Binary logistic analysis revealed that age (OR 1.027, 95% CI 1.017‑1.037) and intestinal metaplasia (OR 2.700, 95% CI 2.090‑3.487) were independently related to gastric xanthelasma. Age/sex matched control binary logistic analysis revealed that gastric xanthelasma was significantly associated with presence of intestinal metaplasia (OR 2.338, 95% CI 1.659‑3.297). There was no difference in the number (P=0.427) and location (P>0.05) of gastric xanthelasma for intestinal metaplasia. In conclusion, gastric xanthelasma may be an independent endoscopic warning sign of intestinal metaplasia.
某些相互矛盾的结论表明，胃黄色瘤与 H. pylori、萎缩性胃炎、肠上皮化生和早期胃癌有关。本研究旨在探讨胃黄色瘤与上消化道（GI）内镜或病理特征之间的关系。采用横断面研究方法。共纳入 8634 例接受胃活检且无胃切除术史的患者。根据胃黄色瘤的存在与否将患者分为两组。分析胃黄色瘤与人口统计学特征（包括年龄和性别）、内镜特征（包括消化性溃疡、胆汁反流和胃息肉）或病理特征（包括萎缩、肠上皮化生、H. pylori、异型增生和胃癌）之间的关系。还进行了年龄/性别匹配分析以排除年龄和性别的影响。结果显示，8634 例患者中，3.54%的患者有黄色瘤。胃黄色瘤与年龄（55.76 岁比 49.17 岁，P<0.0001）、十二指肠溃疡（OR 0.860，95%CI 0.369-0.923）、萎缩（OR 1.839，95%CI 1.432-2.362）和肠上皮化生（OR 3.296，95%CI 2.612-4.159）显著相关。二项逻辑回归分析显示，年龄（OR 1.027，95%CI 1.017-1.037）和肠上皮化生（OR 2.700，95%CI 2.090-3.487）是胃黄色瘤的独立相关因素。年龄/性别匹配对照二项逻辑回归分析显示，胃黄色瘤与肠上皮化生显著相关（OR 2.338，95%CI 1.659-3.297）。肠上皮化生的胃黄色瘤数量（P=0.427）和位置（P>0.05）无差异。结论：胃黄色瘤可能是肠上皮化生的独立内镜警示标志。
