血液透析患者的心外膜脂肪组织厚度
Epicardial adipose tissue thickness in hemodialysis patients.
作者信息
Altun Burak, Tasolar Hakan, Eren Necmi, Binnetoğlu Emine, Altun Mehzat, Temiz Ahmet, Gazi Emine, Barutcu Ahmet, Altunoren Orcun, Colkesen Yucel, Uysal Fatma
机构信息
Department of Cardiology, Canakkale Onsekiz Mart University, Canakkale, Turkey.
出版信息
Echocardiography. 2014 Sep;31(8):941-6. doi: 10.1111/echo.12498. Epub 2013 Dec 24.
AIM
Hemodialysis (HD) patients had higher cardiovascular mortality and it is related to atherosclerosis. Epicardial adipose tissue (EAT) thickness is a marker of atherosclerosis and independent predictor of coronary artery disease. The aim of our study was to evaluate the relationship between EAT and carotid intima-media thickness (CIMT) predictors of early atherosclerosis in HD patients.
METHODS
The study included 62 HD patients and 40 healthy controls. EAT thickness and CIMT were measured by echocardiography in all subjects.
RESULTS
Epicardial adipose tissue thickness and CIMT were higher (6.98 ± 1.67 vs. 3.84 ± 0.73 mm, P < 0.001, 0.94 ± 0.17 vs. 0.63 ± 0.11 mm, P < 0.001, respectively) in HD patients than in control subjects. EAT thickness were correlated with CIMT, HD duration, age, and calcium. In addition, HD duration, CIMT, and age were independent predictors of EAT thickness on HD patients in regression analysis.
CONCLUSION
Epicardial adipose tissue thickness may be a useful indicator of early atherosclerosis in HD patients.
目的
血液透析（HD）患者心血管死亡率较高，且与动脉粥样硬化有关。心外膜脂肪组织（EAT）厚度是动脉粥样硬化的一个标志物，也是冠状动脉疾病的独立预测指标。我们研究的目的是评估HD患者中EAT与早期动脉粥样硬化的颈动脉内膜中层厚度（CIMT）预测指标之间的关系。
方法
该研究纳入了62例HD患者和40例健康对照者。所有受试者均通过超声心动图测量EAT厚度和CIMT。
结果
HD患者的心外膜脂肪组织厚度和CIMT均高于对照组（分别为6.98±1.67 vs. 3.84±0.73mm，P<0.001；0.94±0.17 vs. 0.63±0.11mm，P<0.001）。EAT厚度与CIMT、HD病程、年龄和钙相关。此外，在回归分析中，HD病程、CIMT和年龄是HD患者EAT厚度的独立预测指标。
结论
心外膜脂肪组织厚度可能是HD患者早期动脉粥样硬化的一个有用指标。
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