Department of Nephrology, Faculty of Medicine, Dicle University, Diyarbakir, Turkey.
Department of Internal Medicine, Selahattin Eyyübi State Hospital, Diyarbakir, Turkey.
Med Sci Monit. 2020 Feb 7;26:e920233. doi: 10.12659/MSM.920233.
BACKGROUND The main cause of mortality among chronic kidney disease (CKD) patients is cardiovascular disease (CVD). Epicardial adipose tissue (EAT) is considered to be novel cardiovascular risk factor. We assessed EAT in non-dialyzed stage 5 CKD patients and explored the association of EAT with body composition as determined by multi-frequency BIA. MATERIAL AND METHODS The present included 70 stage 5 CKD patients who had not undergone dialysis and 40 healthy control subjects. EAT thickness was assessed by echocardiography. Hydration status and body composition were evaluated by multi-frequency bioelectrical impedance analysis. RESULTS Stage 5 CKD patients had significantly higher EAT thickness than healthy subjects (6.56±1.18 vs. 4.05±1.45, p<0.001). Fat tissue mass, systolic blood pressure (SBP), age, fat tissue index, and body mass index were positively correlated with EAT thickness in the CKD patient group (p<0.05). Lean tissue mass, lean tissue index (LTI), and high-density lipoprotein (HDL) were negatively correlated with EAT thickness in the CKD patient group (p<0.05). Stepwise multiple regression analysis showed that age, SBP, and LTI were independently associated with EAT thickness in CKD patients. CONCLUSIONS We found significantly higher EAT thickness in stage 5 CKD patients who were not on dialysis compared to healthy controls. EAT was significantly associated with age, SBP, and LTI in CKD patients. Interventions to reduce the risk factors associated with EAT thickness might protect against CVD disease in CKD patients.
慢性肾脏病（CKD）患者死亡的主要原因是心血管疾病（CVD）。心外膜脂肪组织（EAT）被认为是一种新的心血管危险因素。我们评估了未透析的 5 期 CKD 患者的 EAT，并通过多频生物电阻抗分析（BIA）探索了 EAT 与身体成分的相关性。
本研究纳入了 70 名未透析的 5 期 CKD 患者和 40 名健康对照者。通过超声心动图评估 EAT 厚度。通过多频生物电阻抗分析评估水合状态和身体成分。
5 期 CKD 患者的 EAT 厚度明显高于健康对照组（6.56±1.18 比 4.05±1.45，p<0.001）。脂肪组织质量、收缩压（SBP）、年龄、脂肪组织指数和体重指数与 CKD 患者组的 EAT 厚度呈正相关（p<0.05）。瘦组织质量、瘦组织指数（LTI）和高密度脂蛋白（HDL）与 CKD 患者组的 EAT 厚度呈负相关（p<0.05）。逐步多元回归分析显示，年龄、SBP 和 LTI 与 CKD 患者的 EAT 厚度独立相关。
我们发现未透析的 5 期 CKD 患者的 EAT 厚度明显高于健康对照组。EAT 与 CKD 患者的年龄、SBP 和 LTI 显著相关。降低与 EAT 厚度相关的危险因素的干预措施可能有助于预防 CKD 患者的 CVD 疾病。
